Radiation-induced coronary artery disease in Hodgkin's disease.

Abstract

PURPOSE:

Secondary malignant tumours and cardiovascular complications are of great importance among the late complications after treatment for Hodgkin's disease (HD) because they may significantly reduce the patients' life expectancy. We report on coronary artery disease (CAD) after treatment for HD.

METHODS AND MATERIALS:

We present the case of two female patients with HD who received mediastinal irradiation after which complete remission was achieved. In 12 and 19 years after the onset of the disease, control examinations revealed ischaemic heart disease, which was confirmed by coronary arteriography and solved by stent implantation in one of the patients and bypass surgery in the other one.

CONCLUSIONS:

Ischaemic heart disease was due to early CAD, which was associated with mediastinal irradiation accompanied by hypothyroidism, hyperlipidaemia and, possibly, early menopause, all posing an increased risk for the cardiologic disease. Our cases may serve as a warning example to carefully plan the management (low dose, involved field irradiation) of newly diagnosed patients as well as the cardiologic follow-up of patients with HD.

• Authors: Zsófia Miltényi, Katalin Keresztes, Ildikó Garai, István Edes, Zoltán Galajda, László Tóth, Arpád Illés
• Journal: Cardiovascular radiation medicine (Cardiovasc Radiat Med) 2004 Jan-Mar Vol. 5 Issue 1 Pg. 38-43 ISSN: 1522-1865 [Print] United States
• PMID: 15275631 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright 2004 Elsevier Inc.

Topics

• Adult
• Angioplasty, Balloon, Coronary (methods)
• Biopsy, Needle
• Brachytherapy (adverse effects)
• Coronary Angiography
• Coronary Stenosis (etiology, pathology, therapy)
• Female
• Follow-Up Studies
• Hodgkin Disease (diagnosis, radiotherapy)
• Humans
• Immunohistochemistry
• Radiation Injuries (pathology, therapy)
• Radiotherapy Dosage
• Severity of Illness Index
• Stents
• Time Factors
• Treatment Outcome