MR imaging of mouse leptomeningeal metastases.

Abstract

To develop new treatment strategies for patients with leptomeningeal metastases (LM), potential therapeutic agents have to be tested in murine models first. In vivo magnetic resonance imaging has an additive value in non-invasive monitoring of the effects of therapeutic agents on LM. Previously, we described a reproducible mouse model for B16F-10 melanoma LM. In this paper, we visualize leptomeningeal melanoma metastases in mice on both T2 weighted MR images and gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) enhanced T1 weighted MR images, using a 4.7T MR spectrometer. We conclude that both MR sequences can be used to detect and monitor LM of melanoma cells in mice. Our data further suggest that LM are more clearly visualized using T1 weighted Gd-DTPA enhanced subtraction imaging than T2 weighted imaging.

• Authors: Dieta Brandsma, Martin J B Taphoorn, Jaap C Reijneveld, Thomas M Nas, Emile E Voest, Klaas Nicolay, Erwin Blezer
• Journal: Journal of neuro-oncology (J Neurooncol) Vol. 68 Issue 2 Pg. 123-30 (Jun 2004) ISSN: 0167-594X [Print] United States
• PMID: 15218948 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Contrast Media
• Gadolinium DTPA

Topics

• Animals
• Contrast Media
• Disease Models, Animal
• Gadolinium DTPA
• Magnetic Resonance Imaging
• Male
• Melanoma, Experimental (pathology, secondary)
• Meningeal Neoplasms (pathology, secondary)
• Mice
• Mice, Inbred BALB C