Lack of evidence of encephalopathy related to pertussis vaccine: active surveillance by IMPACT, Canada, 1993-2002.

Abstract

To assess whether pertussis-containing vaccines cause encephalitis or encephalopathy, the IMPACT network of Canadian pediatric centers screened more than 12,000 admissions for neurologic disorders between 1993 and 2002. Seven cases of encephalopathy began within 7 days after pertussis vaccination, but a more likely cause was found in each instance. No attributable case followed administration of >6.5 million doses of vaccine.

• Authors: Dorothy L Moore, Nicole Le Saux, David Scheifele, Scott A Halperin, Members of the Canadian Paediatric Society/Health Canada Immunization Monitoring Program Active (IMPACT)
• Journal: The Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 23 Issue 6 Pg. 568-71 (Jun 2004) ISSN: 0891-3668 [Print] United States
• PMID: 15194842 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Pertussis Vaccine

Topics

• Age Distribution
• Canada (epidemiology)
• Child, Preschool
• Data Collection
• Encephalitis (chemically induced, epidemiology)
• Female
• Humans
• Incidence
• Infant
• Male
• Neurotoxicity Syndromes (epidemiology, etiology)
• Pertussis Vaccine (administration & dosage, adverse effects)
• Retrospective Studies
• Risk Assessment
• Sex Distribution
• Whooping Cough (prevention & control)