Abstract | OBJECTIVES: METHODS: RESULTS: Painful and ruptured tendons showed a significant decrease (median 2-fold) in the expression of versican mRNA, in contrast to an increased expression (median 8-fold) of type I collagen alpha1 mRNA in painful tendons. Versican splice variants V0 and V1 mRNA were readily detected in normal samples, V3 levels were substantially lower, and V2 levels were more variable. Each of V1, V2 and V3 mRNA showed significant decreases in expression in painful and ruptured tendons, but V0 was not significantly changed. CONCLUSIONS: Changes in versican expression relative to that of collagen, and alterations in the balance of versican splice variants, may contribute to changes in matrix structure and function in tendinopathies.
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Authors | A N Corps, A H N Robinson, T Movin, M L Costa, D C Ireland, B L Hazleman, G P Riley |
Journal | Rheumatology (Oxford, England)
(Rheumatology (Oxford))
Vol. 43
Issue 8
Pg. 969-72
(Aug 2004)
ISSN: 1462-0324 [Print] England |
PMID | 15138331
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Chondroitin Sulfate Proteoglycans
- Collagen Type I
- Lectins, C-Type
- Proteoglycans
- RNA, Messenger
- VCAN protein, human
- Versicans
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Topics |
- Achilles Tendon
(physiology)
- Adult
- Aged
- Aged, 80 and over
- Base Sequence
- Chondroitin Sulfate Proteoglycans
(genetics)
- Collagen Type I
(genetics)
- Humans
- Lectins, C-Type
- Middle Aged
- Pain
(genetics)
- Proteoglycans
(genetics)
- RNA Splicing
(genetics)
- RNA, Messenger
(analysis)
- Reverse Transcriptase Polymerase Chain Reaction
(methods)
- Tendinopathy
(genetics)
- Tendon Injuries
(genetics)
- Versicans
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