Abstract | BACKGROUND: METHODS: RESULTS: Significant improvement in LDL-C goal achievement was found for patients who switched to rosuvastatin 10 mg, compared with patients who remained on atorvastatin 10 mg (86% vs 80%, P <.05), simvastatin 20 mg (86% vs 72%, P <.0001), and pravastatin 40 mg (88% vs 66%, P <.0001), and between patients switched to rosuvastatin 20 mg and those who remained on atorvastatin 20 mg (90% vs 84%, P <.01). Similar results were found for achievement of the European combined LDL-C and total cholesterol goals and National Cholesterol Education Program Adult Treatment Panel III LDL-C goals. All statins were well tolerated over 16 weeks. CONCLUSIONS: We demonstrated that switching to a more efficacious statin is an effective strategy to improve lipid goal achievement in patients requiring lipid-lowering therapy.
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Authors | Herbert Schuster, Philip J Barter, Steen Stender, Raphael C Cheung, Jacques Bonnet, Jonathan M Morrell, Claire Watkins, David Kallend, Ali Raza, Effective Reductions in Cholesterol Using Rosuvastatin Therapy I study group |
Journal | American heart journal
(Am Heart J)
Vol. 147
Issue 4
Pg. 705-13
(Apr 2004)
ISSN: 1097-6744 [Electronic] United States |
PMID | 15077101
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cholesterol, HDL
- Cholesterol, LDL
- Fluorobenzenes
- Heptanoic Acids
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Pyrimidines
- Pyrroles
- Sulfonamides
- Triglycerides
- Rosuvastatin Calcium
- Cholesterol
- Atorvastatin
- Simvastatin
- Pravastatin
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Topics |
- Aged
- Arteriosclerosis
(complications)
- Atorvastatin
- Cholesterol
(blood)
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Coronary Disease
(complications)
- Diabetes Mellitus, Type 2
(complications)
- Female
- Fluorobenzenes
(therapeutic use)
- Heptanoic Acids
(therapeutic use)
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(therapeutic use)
- Hypercholesterolemia
(complications, drug therapy)
- Logistic Models
- Male
- Middle Aged
- Pravastatin
(therapeutic use)
- Pyrimidines
(therapeutic use)
- Pyrroles
(therapeutic use)
- Rosuvastatin Calcium
- Simvastatin
(therapeutic use)
- Sulfonamides
(therapeutic use)
- Triglycerides
(blood)
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