Chronic
myocarditis is the main pathological finding associated with
Chagas disease-related morbidity. Concentrations of CCL2, CCL3,
tumor necrosis factor (
TNF)-alpha, and
brain natriuretic peptide (BNP) were evaluated in plasma samples obtained from patients with different clinical forms of chronic chagasic
cardiomyopathy. Patients with more-severe
Chagas disease had elevated plasma concentrations of
TNF-alpha, CCL2, and BNP, and there was a good correlation between levels of these
proteins (especially
TNF-alpha ) and the degree of heart dysfunction. Indeed,
TNF-alpha level was an excellent predictor of
heart failure. Peripheral blood mononuclear cell samples obtained from patients with mild or severe chagasic
cardiomyopathy produced greater amounts of
TNF-alpha and CCL2 than did those obtained from noninfected individuals. The elevation of
TNF-alpha and CCL2 levels in the plasma of patients appears to be secondary to the degree of heart dysfunction, whereas spontaneous production of
TNF-alpha and CCL2 by mononuclear cells is secondary not only to heart dysfunction, but also to the underlying
inflammation in the heart of chagasic patients. Measurement of the
TNF-alpha level could be a useful tool in the identification of patients with heart dysfunction who may benefit from further investigation and treatment.