Abstract | OBJECTIVE: METHODS: To predict the prognosis and response to the chemotherapy, the expression of apoptosis associated- proteins, p53, p21WAF1/CIP1, Bcl-2 and activated caspase-3 was evaluated for tumor samples by immunohistochemistry. RESULTS: Of the analyzed clinicopathological factors, the overexpression of p53 was frequently observed in endocervical-type adenocarcinoma, nonresponders to chemotherapy and the grade 0 histologic effect of the chemotherapy. Positive staining of Bcl-2 was frequently observed in the early stage and had a better prognosis than for patients with the negative staining; however, there was no correlation between responders and nonresponders to chemotherapy. The expression of p21WAF1/CIP1 and caspase-3 was not correlated to the clinicopathological factors. CONCLUSION: In this study, the overexpression of p53 was found to be a factor to predict the chemoresistance and positive expression of Bcl-2 indicated as a better prognostic value. For p21WAF1/CIP1 and caspase-3, further analysis is necessary.
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Authors | Tsuyoshi Saito, Masaki Takehara, Ryoichi Tanaka, Rong Lee, Miyabi Horie, Koya Wataba, Eiki Ito, Ryuichi Kudo |
Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 92
Issue 1
Pg. 284-92
(Jan 2004)
ISSN: 0090-8258 [Print] United States |
PMID | 14751172
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- CDKN1A protein, human
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Proto-Oncogene Proteins c-bcl-2
- Tumor Suppressor Protein p53
- Mitomycin
- Aclarubicin
- CASP3 protein, human
- Caspase 3
- Caspases
- Cisplatin
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Topics |
- Aclarubicin
(administration & dosage)
- Adenocarcinoma
(drug therapy, metabolism, radiotherapy, surgery)
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Apoptosis
(physiology)
- Caspase 3
- Caspases
(biosynthesis)
- Cisplatin
(administration & dosage)
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
(biosynthesis)
- Female
- Humans
- Immunohistochemistry
- Middle Aged
- Mitomycin
(administration & dosage)
- Neoadjuvant Therapy
- Prognosis
- Proto-Oncogene Proteins c-bcl-2
(biosynthesis)
- Tumor Suppressor Protein p53
(biosynthesis)
- Uterine Cervical Neoplasms
(drug therapy, metabolism, radiotherapy, surgery)
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