Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: The application of the physical-chemical approach to acid-base analysis has led to recent developments in the identification and quantification and understanding of mechanisms for acid-base disorders commonly found in critically ill patients. Examples include a better understanding of the role of electrolytes (especially sodium and chloride) and weak acids in the pathophysiology of acid-base disorders, the implication of acid-base derangements on the inflammatory process and organ perfusion, and the importance of resuscitation fluid composition. SUMMARY: By adopting a physical-chemical approach to acid-base analysis we are gaining insight to the complexities of acid-base disorders and how their treatments may affect outcome.
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Authors | Kyle J Gunnerson, John A Kellum |
Journal | Current opinion in critical care
(Curr Opin Crit Care)
Vol. 9
Issue 6
Pg. 468-73
(Dec 2003)
ISSN: 1070-5295 [Print] United States |
PMID | 14639065
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Acid-Base Imbalance
(diagnosis, etiology, physiopathology, prevention & control)
- Acidosis
(diagnosis, etiology, physiopathology, prevention & control)
- Critical Care
(methods)
- Fluid Therapy
(methods)
- Glucose
(metabolism)
- Humans
- Insulin
(therapeutic use)
- Renal Replacement Therapy
(adverse effects)
- Respiration, Artificial
(adverse effects)
- Water-Electrolyte Balance
(physiology)
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