Abstract | BACKGROUND/AIMS: Reactive oxygen radicals play an important role in various forms of liver injury. In this study, we evaluated the efficacy of edaravone, a newly synthesized free radical scavenger, in its clinical dosage on an experimental model of acute liver injury in rats. METHODS: The clinical dose of edaravone (3 mg/kg) was intravenously administered immediately and 3 h after intraperitoneal administration of carbon tetrachloride (CCl4) in rats. Histological evaluation including apoptosis and cytokine profiles were examined. RESULTS: CONCLUSION:
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Authors | Nobuhiro Nakamoto, Shinichiro Tada, Kaori Kameyama, Kumi Kitamura, Satoshi Kurita, Yoshimasa Saito, Hidetsugu Saito, Hiromasa Ishii |
Journal | Free radical research
(Free Radic Res)
Vol. 37
Issue 8
Pg. 849-59
(Aug 2003)
ISSN: 1071-5762 [Print] England |
PMID | 14567445
(Publication Type: Journal Article)
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Chemical References |
- Aldehydes
- Cytokines
- Free Radical Scavengers
- Growth Inhibitors
- Interleukin-6
- Reactive Oxygen Species
- Tumor Necrosis Factor-alpha
- Interleukin-10
- Interleukin-4
- 8-Hydroxy-2'-Deoxyguanosine
- Alanine Transaminase
- Deoxyguanosine
- 4-hydroxy-2-nonenal
- Edaravone
- Oxygen
- Antipyrine
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Topics |
- 8-Hydroxy-2'-Deoxyguanosine
- Acute Disease
- Alanine Transaminase
(blood)
- Aldehydes
(metabolism)
- Animals
- Antipyrine
(analogs & derivatives, pharmacology)
- Apoptosis
- Cell Death
- Cytokines
(biosynthesis, metabolism)
- Deoxyguanosine
(analogs & derivatives, metabolism)
- Edaravone
- Free Radical Scavengers
(pharmacology)
- Growth Inhibitors
(pharmacology)
- Immunohistochemistry
- In Situ Nick-End Labeling
- Interleukin-10
(metabolism)
- Interleukin-4
(metabolism)
- Interleukin-6
(metabolism)
- Liver
(injuries, metabolism)
- Male
- Models, Chemical
- Necrosis
- Oxygen
(metabolism)
- Rats
- Rats, Wistar
- Reactive Oxygen Species
- Reverse Transcriptase Polymerase Chain Reaction
- Tumor Necrosis Factor-alpha
(metabolism)
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