Abstract | BACKGROUND: METHODS: We measured BHR [provocative concentration causing a 20% fall (PC(20)) in forced expiratory volume in 1 s (FEV(1))] to AMP and methacholine, and induced sputum cells in 16 rhinitis patients before and during the 2001 grass pollen season. RESULTS: There was a decrease in PC(20) methacholine during pollen exposure (geometric mean PC(20) from 3.22 to 1.73 mg/ml, p = 0.0023), whereas no reduction was observed for PC(20) AMP (p = 0.11). There was no increase in sputum eosinophils [pre: 0.69% (95% confidence interval 0.22-2.07); during: 1.85 (0.55- 5.6), p = 0.31]. Although the correlation of log PC(20) methacholine and log PC(20) AMP at baseline was good (r = 0.76, p = 0.001), individual seasonal changes (doubling concentrations) in PC(20) methacholine were not correlated with changes in PC(20) AMP (rho = 0.21, p = 0.44). There was no correlation between baseline log PC(20) methacholine or seasonal changes in PC(20) methacholine and sputum eosinophils (p > 0.12, all correlations). In contrast, there was a significant correlation between seasonal changes in PC(20) AMP and changes in sputum eosinophils (rho = -0.59, p = 0.025). CONCLUSIONS: These data show dissimilarity between seasonal changes in PC(20) AMP and methacholine in patients with seasonal allergic rhinitis. Moreover, PC(20) AMP seems to be more closely related to sputum eosinophils than PC(20) methacholine. The clinical significance of this discrepancy is unclear.
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Authors | Jutta Beier, Kai Michael Beeh, Oliver Kornmann, Emila Morankic, Nicole Ritter, Roland Buhl |
Journal | International archives of allergy and immunology
(Int Arch Allergy Immunol)
Vol. 132
Issue 1
Pg. 76-81
(Sep 2003)
ISSN: 1018-2438 [Print] Switzerland |
PMID | 14555861
(Publication Type: Journal Article)
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Copyright | Copyright 2003 S. Karger AG, Basel |
Chemical References |
- Bronchoconstrictor Agents
- Methacholine Chloride
- Adenosine Monophosphate
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Topics |
- Adenosine Monophosphate
(pharmacology)
- Adult
- Bronchial Hyperreactivity
(blood, immunology)
- Bronchoconstrictor Agents
(pharmacology)
- Cell Count
- Eosinophils
(immunology)
- Female
- Forced Expiratory Volume
(immunology)
- Humans
- Male
- Methacholine Chloride
(pharmacology)
- Middle Aged
- Poaceae
(immunology)
- Pollen
(immunology)
- Rhinitis, Allergic, Seasonal
(blood, immunology)
- Seasons
- Sputum
(cytology, drug effects)
- Statistics, Nonparametric
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