Osteoclastogenesis inhibitory factor/osteoprotegerin in synovial fluid from patients with temporomandibular disorders.

Abstract

The goal of this study was to measure the activities of osteoclastogenesis inhibitory factor/osteoprotegerin (OCIF/OPG), interleukin-1beta (IL-1beta), and tumour necrosis factor-alpha (TNF-alpha) in synovial fluid from 24 patients with internal derangement and 26 with osteoarthritis of the temporomandibular joint (TMJ). Five asymptomatic healthy volunteers were studied as control. Concentrations of OCIF/OPG, IL-1beta, and TNF-alpha were determined by enzyme-linked immunosorbent assay. The mean OCIF/OPG concentration in the patients with osteoarthritis (71 pg/ml) was significantly lower than those in the patients with internal derangement (160 pg/ml, P< 0.05) and the healthy volunteers (196 pg/ml, P< 0.01). In contrast, the IL-1beta and TNF-alpha concentrations were similar in all three groups. These results suggest that OCIF/OPG is associated with the pathogenesis of osteoarthritis of the TMJ. Perhaps, decreased OCIF/OPG concentrations promote osteoclastic activity and induce osteoarthritis of the TMJ.

• Authors: K Kaneyama, N Segami, M Nishimura, J Sato, T Suzuki, K Fujimura
• Journal: International journal of oral and maxillofacial surgery (Int J Oral Maxillofac Surg) Vol. 32 Issue 4 Pg. 404-7 (Aug 2003) ISSN: 0901-5027 [Print] Denmark
• PMID: 14505625 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Glycoproteins
• Interleukin-1
• Osteoprotegerin
• Receptors, Cytoplasmic and Nuclear
• Receptors, Tumor Necrosis Factor
• TNFRSF11B protein, human
• Tumor Necrosis Factor-alpha

Topics

• Adolescent
• Adult
• Aged
• Child
• Female
• Glycoproteins (analysis)
• Humans
• Interleukin-1 (analysis)
• Joint Dislocations (metabolism)
• Male
• Middle Aged
• Osteoarthritis (metabolism)
• Osteoprotegerin
• Receptors, Cytoplasmic and Nuclear (analysis)
• Receptors, Tumor Necrosis Factor (analysis)
• Synovial Fluid (chemistry)
• Temporomandibular Joint Disorders (metabolism)
• Tumor Necrosis Factor-alpha (analysis)