Synergism of environmental carcinogens and promoters on bladder cancer development initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine in F344 rats.

Abstract

Synergistic or additive effects of combined treatments with carcinogens or promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)-initiated rat bladder carcinogenesis were examined. Male F344 rats were given BBN as an initiator followed by low doses of 3 sodium salts (sodium bicarbonate, sodium L-ascorbate and sodium citrate) and/or 3 antioxidants (butylated hydroxyanisole, butylated hydroxytoluene and tertiary butylhydroxyquinone). Combined treatments with 3 sodium salts or 3 antioxidants, and especially all 6 chemicals together promoted bladder carcinogenesis. In addition, these combined treatments were associated with increased DNA synthesis of the bladder epithelium. Combined administration of the carcinogens, o-anisidine, p-cresidine, and 4-chloro-o-phenylenediamine at low doses also enhanced BBN-initiated bladder carcinogenesis. These results indicate that environmental carcinogens or promoters can exert synergistic or additive actions on bladder cancer induction.

• Authors: S Ono, Y Kurata, Y Shichino, M Sano, S Fukushima
• Journal: Japanese journal of cancer research : Gann (Jpn J Cancer Res) Vol. 83 Issue 9 Pg. 955-63 (Sep 1992) ISSN: 0910-5050 [Print] Japan
• PMID: 1429206 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carcinogens
• DNA, Neoplasm
• Environmental Pollutants
• Butylhydroxybutylnitrosamine

Topics

• Animals
• Body Weight
• Butylhydroxybutylnitrosamine
• Carcinogens
• DNA, Neoplasm (metabolism)
• Drug Synergism
• Environmental Pollutants (toxicity)
• Feeding Behavior
• Male
• Organ Size
• Rats
• Rats, Inbred F344
• Urinary Bladder Neoplasms (chemically induced)