[Preventive hepatitis B vaccination of hospital staff].

Abstract

UNLABELLED:

In March 1990, a vaccination campaign against hepatitis B was organized in a municipal hospital in Copenhagen (Bispebjerg Hospital). The hospital staff (830 subjects) at risk of infection with hepatitis B were offered vaccination with Engerix B. The vaccination was given as Engerix B (recombinant DNA vaccine) in muscle deltoid after 0, 1 and 6 months. Antibody level was measured after one month. A total of 362 (44%) received vaccination against hepatitis B and 86% of these completed the vaccination schedule and received at least three vaccinations. 95% of the vaccinated subjects were protected after three vaccinations (HBsAg more than 10 IU/l).

CONCLUSION:

The recombinant DNA vaccine does not differ from the plasma-derived vaccine concerning immunogenicity and adverse reactions. There was a low compliance with the vaccination campaign, especially among doctors (35%) and laboratory technicians (35%), despite central organization.

• Authors: L S Jepsen, A C Thomsen
• Journal: Ugeskrift for laeger (Ugeskr Laeger) Vol. 154 Issue 36 Pg. 2421-3 (Aug 31 1992) ISSN: 0041-5782 [Print] Denmark
• Vernacular Title: Profylaktisk hepatitis B vaccination af et hospitalspersonale.
• PMID: 1413161 (Publication Type: English Abstract, Journal Article)

Chemical References

• Hepatitis B Vaccines
• Vaccines, Synthetic

Topics

• Denmark
• Hepatitis B (immunology, prevention & control)
• Hepatitis B Vaccines (administration & dosage)
• Humans
• Immunization
• Personnel, Hospital
• Vaccines, Synthetic (administration & dosage)