DNA Vaccines

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622 relevant articles (104 outcomes, 74 trials/studies) found for this Bio-Agent

Description: Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.

Also Known As:

Vaccines, DNA; DNA Vaccines, Naked; DNA Vaccines, Recombinant; Vaccines, Naked DNA; Vaccines, Nucleic Acid; Vaccines, Polynucleotide; Naked DNA Vaccines; Nucleic Acid Vaccines; Polynucleotide Vaccines; Recombinant DNA Vaccines; Vaccines, Recombinant DNA

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Bio-Agent Context: Research Results

Experts

1.	Wu, T-C: 6 articles (12/2007 - 12/2003)
2.	Thalhamer, Josef: 6 articles (07/2006 - 01/2003)
3.	Hung, Chien-Fu: 5 articles (12/2007 - 12/2003)
4.	Wolchok, Jedd D: 5 articles (11/2007 - 10/2003)
5.	Weiss, Richard: 5 articles (07/2006 - 01/2003)
6.	Scheiblhofer, Sandra: 5 articles (07/2006 - 01/2003)
7.	Reisfeld, Ralph A: 3 articles (04/2008 - 03/2004)
8.	Rice, Jason: 3 articles (02/2008 - 10/2004)
9.	Hartl, Arnulf: 3 articles (07/2006 - 01/2003)
10.	Boyd, David A K: 3 articles (05/2005 - 05/2004)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2001 - "Despite highly promising results in many animal tumor models the efficacy of nucleic acid vaccines and adjuvants in the clinic remains to be seen." 12/01/2003 - "If these trials prove DNA vaccines to be clinically effective, they could lead to the development of a new generation of therapies for the treatment and/or prevention of cancer." 08/01/2009 - "In conclusion, xenogeneic immunization with TH-derived DNA vaccines is effective against NB, and may open a new venue for a novel and effective immunotherapeutic strategy against this challenging childhood tumor." 08/01/2004 - "The therapeutic efficacy of DNA vaccines was correlated with tumor infiltration of CD8+ T cells. " 06/01/2004 - "It is anticipated that such research efforts will contribute toward the rational design of future DNA vaccines that will be effective for prevention and treatment of human cancer." Order ALL the reference details at left...
2.	Infection 03/01/2008 - "Immunizations with IC/DNA vaccines led to an anti-woodchuck hepatitis virus surface antibody response and significant reductions of viral load and antigenemia, suggesting that such a strategy may be effective against chronic HBV infection." 06/01/2003 - "For example, immunization with DNA vaccines expressing the gene for the immunodominant 35000 MW protein, common to Mycobacterium avium and Mycobacterium leprae but absent from the Mycobacterium tuberculosis complex, conferred significant protection against infection with either virulent M. " 03/29/2004 - "These results suggest that in vivo electroporation can be used as an efficient gene delivery system for DNA vaccines to provide efficient protection against viral infection." 07/01/1998 - "Induction of mucosal immunity by targeting DNA vaccines to mucosal surfaces may offer advantages, and an oral vaccine could be effective for controlling infections of the gut mucosa. " 01/01/1998 - "Protective efficacy of DNA vaccines against duck hepatitis B virus infection." Order ALL the reference details at left...
3.	Tuberculosis 01/01/2009 - "Use of therapeutic DNA vaccines is a promising strategy against tuberculosis (TB), however, their immunogenicity still needs to be improved. " 10/01/2003 - "Immune response and protective efficacy for the combination of four tuberculosis DNA vaccines were evaluated in this study. " 11/01/2001 - "[Evaluation of protective efficacy of two tuberculosis DNA vaccines by lung histopathological analysis]" 01/15/1999 - "Immunogenicity and protective efficacy of tuberculosis DNA vaccines encoding putative phosphate transport receptors." 09/01/1999 - "These results suggest that the tuberculosis DNA vaccines were able to elicit substantial immune responses in suitably vaccinated mice, but further refinements to the constructs or the use of alternative immunization strategies will be needed to improve the efficacy of these vaccine candidates." Order ALL the reference details at left...
4.	Human Influenza (Influenza) 02/26/2007 - "We conclude that IFN-alpha 6 has antiviral and immunomodulatory effects, which improve efficacy of DNA vaccines for enhanced control of influenza." 07/15/2009 - "In the current study, we evaluated a novel strategy that combines the immunogenicity of influenza VLPs and the advantages of DNA vaccines. " 09/01/2009 - "DNA vaccines are an attractive choice owing to their capacity to induce robust humoral and cellular immune responses at low doses and because they can be developed and manufactured rapidly to more effectively meet the threat of an influenza epidemic or pandemic. " 03/01/2009 - "Our work may contribute to improvement of HA-based influenza DNA vaccines." 01/01/2009 - "Finally, we discuss the advances made in the use of DNA vaccines to prevent avian H5N1 influenza." Order ALL the reference details at left...
5.	Communicable Diseases (Infectious Diseases) 05/01/1997 - "DNA vaccines have been demonstrated to be effective in inducing protective cell-mediated immune responses in animal models of infectious disease. " 08/20/1999 - "The immunogenicity and protective efficacy of DNA vaccines have been amply demonstrated in numerous animal models of infectious disease. " 09/01/2006 - "This review provides an overview of studies employing particle-mediated epidermal delivery (PMED) or the gene gun to administer DNA vaccines for infectious diseases in preclinical studies employing large animal models and in human clinical trials. " 04/01/2000 - "From a series of preclinical studies and animal experiments, we have been able to demonstrate that DNA vaccines are a promising tool in strategies for protecting hosts from a variety of infectious diseases. " 04/16/2008 - "However, there have been no reports to identify the similarities and differences between these two leading physical delivery methods for DNA vaccines against infectious disease targets. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Antigens
2.	Vaccines
3.	DNA (Deoxyribonucleic Acid)
4.	Proteins (Proteins, Gene)
5.	Autoantigens
6.	Interleukin-12 (IL 12)
7.	butyl 3-(1H-tetrazol-5-yl)oxanilate (MTB)
8.	Antibodies
9.	Epitopes
10.	Codon (Codons)

Related Therapies and Procedures

1.	Immunotherapy
2.	Drug Therapy (Chemotherapy)
3.	Therapeutics
4.	Fluid Therapy (Oral Rehydration Therapy)
5.	Bioreactors

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