Abstract |
Interleukin-10 (IL-10) is an important cytokine in the down-regulation of inflammatory responses, and it has been reported that a low plasma concentration of IL-10 is associated with severe anemia and cerebral malaria in Plasmodium falciparum infections. The IL-10 gene is located on chromosome 1q31-32, and a promoter polymorphism (-1082G/A) is known to affect IL-10 protein production. In order to examine the possible association of the -1082G/A polymorphism with the severity of malaria, we studied 203 mild malaria, 164 non-cerebral severe malaria, and 109 cerebral malaria patients living in northwest Thailand. The genotyping was performed by a fluorescence resonance energy transfer (FRET) method. The frequencies of a major allele -1082A in mild malaria, in non-cerebral severe malaria, and in cerebral malaria patients were 92.6%, 92.1%, and 92.7% respectively. Our results showed no significant association of the -1082G/A polymorphism with the severity of malaria.
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Authors | Jun Ohashi, Izumi Naka, Jintana Patarapotikul, Hathairad Hananantachai, Sornchai Looareesuwan, Katsushi Tokunaga |
Journal | The Southeast Asian journal of tropical medicine and public health
(Southeast Asian J Trop Med Public Health)
Vol. 33 Suppl 3
Pg. 5-7
( 2002)
ISSN: 0125-1562 [Print] Thailand |
PMID | 12971465
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- DNA Primers
- Interleukin-10
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Topics |
- Adolescent
- Adult
- Base Sequence
- DNA Primers
- Humans
- Interleukin-10
(genetics)
- Malaria, Falciparum
(genetics, physiopathology)
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Severity of Illness Index
- Thailand
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