Significance of an exaggerated meal-stimulated gastrin response in pathogenesis of Helicobacter pylori-negative duodenal ulcer.

Abstract

The aim of this study was to clarify the pathogenesis of Helicobacter pylori-negative duodenal ulcer (DU) by investigating the meal-stimulated serum gastrin (SG) response. The subjects were 9 patients with H. pylori-negative DU, 28 H. pylori-positive DU, 11 H. pylori-positive volunteers, and 30 H. pylori-negative volunteers. Blood samples were taken before and after consumption of a test meal. The integrated 1-hr gastrin response (IGR) was taken to be the area under the SG time curve, calculated by the trapezoid method. H. pylori infection status was determined by histology, serology, and the [13C] urea breath test. The mean basal SG concentration was lower in the H. pylori-negative DU patients than in the H. pylori-positive DU patients, but an exaggerated IGR was observed in three patients (33.3%) with H. pylori-negative DU. In conclusion, our findings indicate that an exaggerated meal-stimulated gastrin response may contribute to the pathogenesis of H. pylori-negative DU.

• Authors: Tomoari Kamada, Ken Haruma, Hiroaki Kusunoki, Masaki Miyamoto, Masanori Ito, Yasuhiko Kitadai, Masaharu Yoshihara, Kazuaki Chayama, Kazumasa Tahara, Yuzuru Kawamura
• Journal: Digestive diseases and sciences (Dig Dis Sci) Vol. 48 Issue 4 Pg. 644-51 (Apr 2003) ISSN: 0163-2116 [Print] United States
• PMID: 12741450 (Publication Type: Journal Article)

Chemical References

• Gastrins
• Pepsinogen A

Topics

• Adolescent
• Adult
• Breath Tests
• Duodenal Ulcer (diagnosis, physiopathology)
• Duodenoscopy
• Female
• Gastrins (blood)
• Helicobacter Infections (diagnosis, physiopathology)
• Helicobacter pylori
• Humans
• Male
• Middle Aged
• Pepsinogen A (blood)
• Postprandial Period (physiology)
• Risk Factors