Effects of Ginkgo biloba extract on acute cerebral ischemia in rats analyzed by magnetic resonance spectroscopy.

Abstract

AIM:

To study the effect of Ginkgo biloba extract (GbE) on acute cerebral ischemia in rats.

METHODS:

The rats were randomly divided into four groups: sham-operated group (group I as control), ischemic group (group II), the prophylactic (GbE premedication) group (group III) and GbE-treatment group (group IV). Magnetic resonance spectroscopy (MRS) was carried out to dynamically monitor the changes in biochemical metabolic variations 48 h after cerebral ischemia and effects of GbE (100 mg/kg, ip, qd).

RESULTS:

(1) Lactate (Lac) peak could be detectable at the infarction area 90 min after acute cerebral ischemia and increased with time. Lac peak in the prophylactic group was elevated slightly (P<0.01, n=6), whereas in the treatment group the elevation of Lac was more remarkable than that in the prophylactic group (P<0.05, n=6). (2) In the ischemic group, the level of N-acetyl aspartate (NAA) was decreased within 4 h after ischemia (P<0.05, n=6), and the decline persisted (P<0.01, n=6). In the treatment group and prophylactic group, NAA was decreased slightly after 24 h (P<0.05, n=6). (3)Twenty-four hours after ischemia, in both ischemic group and treatment group, choline (Cho) was elevated slightly (P<0.05, n=6) and creatine (Cr) was decreased slightly (P<0.05, n=6), but in the prophylactic group these changes occurred only after 48 h.

CONCLUSION:

GbE could prevent and treat acute cerebral ischemia. The effectiveness was more satisfactory when GbE was used preventively.

• Authors: Hai Peng, Yue-Fen Li, Sheng-Gang Sun
• Journal: Acta pharmacologica Sinica (Acta Pharmacol Sin) Vol. 24 Issue 5 Pg. 467-71 (May 2003) ISSN: 1671-4083 [Print] United States
• PMID: 12740184 (Publication Type: Journal Article)

Chemical References

• Drugs, Chinese Herbal
• Lactates
• Aspartic Acid
• N-acetylaspartate
• Creatine
• Choline

Topics

• Animals
• Aspartic Acid (analogs & derivatives, metabolism)
• Brain Ischemia (drug therapy, metabolism, pathology, prevention & control)
• Choline (metabolism)
• Creatine (metabolism)
• Drugs, Chinese Herbal (isolation & purification, therapeutic use)
• Ginkgo biloba (chemistry)
• Hippocampus (drug effects, metabolism, pathology)
• Lactates (metabolism)
• Magnetic Resonance Spectroscopy
• Plants, Medicinal (chemistry)
• Random Allocation
• Rats
• Rats, Sprague-Dawley