[Experimental study on protective effective of congsheng capsule in acute cerebral ischemia and improvement of cerebral blood flow and energy metabolism].

Abstract

OBJECTIVE:

To investigate the protective effect of Congsheng capsule (CSC) on acute cerebral ischemia in mice and rats.

METHODS:

Cerebral ischemia model was established by adding FeCl3 to block the blood flow of unilateral middle cerebral artery (MCA) for 30 mins. Acute incomplete cerebral ischemia was induced by ligation of bilateral carotid arteries in rats. Bilateral carotid arteries of old mice were repeatedly ischemia and reperfusion combined with caudal bloodletting to build the cerebral ischemia model. The effect of CSC on neurologic symptom, cerebral infarction size, cerebral water content, cerebral blood flow and cerebral tissue energy metabolism were observed.

RESULTS:

CSC 1, 3, 6 g/kg obviously reduce the size of cerebral infarction and cerebral water content, markedly improve the neurological symptoms and cerebral blood flow; 3, 6 g/kg significantly ameliorate the energy burden.

CONCLUSION:

CSC has anti-cerebral ischemia function through increasing blood supply of cerebral tissue and improve the energy metabolism.

• Authors: L Zhao, Q P Xu, M K Tang
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 21 Issue 5 Pg. 375-7 (May 2001) ISSN: 1003-5370 [Print] China
• PMID: 12577426 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Capsules
• Drugs, Chinese Herbal
• Neuroprotective Agents

Topics

• Animals
• Brain Ischemia (metabolism, physiopathology)
• Capsules
• Cerebrovascular Circulation (drug effects)
• Drugs, Chinese Herbal (pharmacology)
• Energy Metabolism (drug effects)
• Female
• Male
• Mice
• Neuroprotective Agents (pharmacology)
• Rats
• Rats, Wistar
• Reperfusion Injury (metabolism)