[Expression of the neural cell adhesion molecule in human astrocytomas].

Abstract

OBJECTIVE:

To investigate the expression of the neural cell adhesion molecule (NCAM) in human astrocytomas, and evaluate the relationship between NCAM and proliferating cell nuclear antigen (PCNA).

METHODS:

Forty-eight astrocytomas were studied by SP method with monoclonal antibody against NCAM and PCNA proteins.

RESULTS:

All normal brain tissues expressed NCAM; NCAM expression was positive in Grade I-II glioma [95% (19/20)], Grade III glioma [38.9% (7/18)], Grade IV glioma [20% (2/10)] respectively. An inverse correlation was observed between the degree of NCAM expression and that of PCNA (r = -0.657, P < 0.05).

CONCLUSION:

NCAM is a down-regulated factor in the development of the malignancy of astrocytomas; and it is suggested that the reduced NCAM expression might be involved in the development of biological malignancy.

• Authors: C X Huang, S X Hu, B Chen
• Journal: Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University (Hunan Yi Ke Da Xue Xue Bao) Vol. 26 Issue 6 Pg. 543-5 (Dec 28 2001) ISSN: 1000-5625 [Print] China
• PMID: 12536535 (Publication Type: English Abstract, Journal Article)

Chemical References

• Neural Cell Adhesion Molecules
• Proliferating Cell Nuclear Antigen

Topics

• Astrocytoma (metabolism)
• Brain Neoplasms (metabolism)
• Humans
• Neural Cell Adhesion Molecules (biosynthesis, genetics)
• Proliferating Cell Nuclear Antigen (biosynthesis, genetics)