Serum hyaluronan as a possible biomarker of liver insufficiency in cirrhotic patients.

Abstract

Hepatic hyaluronan is a glycosaminoglycan synthesised in the liver mainly by mesenchymal cells and degraded by liver sinusoidal endothelial cells. Serum hyaluronan was measured, using enzyme-linked binding protein assay (Chugai, Japan) in 30 patients with cirrhosis of different etiologies (alcohol n = 15, primary biliary cirrhosis n = 4, hepatitis B n = 5, hepatitis C n = 6). Hyaluronan levels were significantly higher in patients with liver cirrhosis (398 +/- 375.4 ng/ml) than in the controls (36.5 +/- 26.9 ng/ml). There was no significant difference in hialuronan levels between the different etiologies of the disease. Hyaluronan level increased proportionally to the severity of cirrhosis.

• Authors: Anna Grzeszczuk, Sławomir Chlabicz, Anatol Panasiuk
• Journal: Roczniki Akademii Medycznej w Bialymstoku (1995) (Rocz Akad Med Bialymst) Vol. 47 Pg. 80-5 ( 2002) Poland
• PMID: 12533949 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Biomarkers
• Hyaluronic Acid

Topics

• Adult
• Biomarkers (analysis)
• Case-Control Studies
• Disease Progression
• Female
• Humans
• Hyaluronic Acid (analysis, blood)
• Liver Cirrhosis (complications, diagnosis)
• Liver Failure (diagnosis, etiology)
• Liver Function Tests
• Male
• Middle Aged
• Probability
• Prognosis
• Sensitivity and Specificity
• Severity of Illness Index
• Statistics, Nonparametric