Abstract | BACKGROUND AND OBJECTIVES: METHODS: RESULTS: Expression of the alpha6 subunit by metastatic cancer cells was enhanced by IL-1alpha. Metastatic cancer cells also exhibited preferential adherence and invasion to laminin compared with nonmetastatic cancer cells, and this was enhanced by IL-1alpha. CONCLUSIONS: The enhancement of alpha6beta1-integrin by Il-1alpha acting through IL-1RI, as well as the expression of alpha6beta1-integrin, plays an important role in metastasis formation in pancreatic cancer
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Authors | Hirozumi Sawai, Hiromitsu Takeyama, Minoru Yamamoto, Akiyoshi Furuta, Hitoshi Funahashi, Yuji Okada, Mikinori Sato, Moritsugu Tanaka, Tadao Manabe |
Journal | Journal of surgical oncology
(J Surg Oncol)
Vol. 82
Issue 1
Pg. 51-6
(Jan 2003)
ISSN: 0022-4790 [Print] United States |
PMID | 12501168
(Publication Type: Journal Article)
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Copyright | Copyright 2002 Wiley-Liss, Inc. |
Chemical References |
- Extracellular Matrix Proteins
- Integrins
- Interleukin-1
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Topics |
- Carcinoma, Ductal, Breast
(metabolism, pathology)
- Cell Adhesion
- Extracellular Matrix Proteins
(physiology)
- Humans
- Integrins
(biosynthesis, physiology)
- Interleukin-1
(pharmacology)
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Pancreatic Neoplasms
(metabolism, pathology)
- Tumor Cells, Cultured
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