The role of ubiquitin-proteasome pathway in oncogenic signaling.

Abstract	Oncogenic activation of genes that regulate cell proliferation and survival plays a central role in the development of human cancer. This activation is frequently achieved by the aberrant expression of oncogene products due to the gene amplification, enhanced transcription or stabilization of their mRNA or protein. The ubiquitin-proteasome pathway(UPP) is the key player in the intracellular degradation of regulatory proteins in eukaryotes. UPP controls the abundance and activity of important protein regulators of cellular signal transduction including a variety of cellular proto-oncogenes. Alteration of ubiquitination and degradation of these proto-oncogene proteins often occurs during tumorigenesis and critically contributes to cell decisions as per proliferation/differentiation and survival/death. This article attempts to briefly overview the role of UPP in the regulation of several signal transduction pathways that contribute to development of cancer.
Authors	Serge Y Fuchs
Journal	Cancer biology & therapy (Cancer Biol Ther) 2002 Jul-Aug Vol. 1 Issue 4 Pg. 337-41 ISSN: 1538-4047 [Print] United States
PMID	12432242 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S., Review)
Chemical References	CTNNB1 protein, human Cytoskeletal Proteins DNA-Binding Proteins Lymphoid Enhancer-Binding Factor 1 MAS1 protein, human Multienzyme Complexes NF-kappa B Proto-Oncogene Mas RNA, Messenger Trans-Activators Transcription Factors Transforming Growth Factor beta Ubiquitin beta Catenin Cysteine Endopeptidases Proteasome Endopeptidase Complex
Topics	Cell Differentiation Cell Division Cell Survival Cysteine Endopeptidases (metabolism) Cytoskeletal Proteins (metabolism) DNA-Binding Proteins (metabolism) Gene Expression Regulation, Neoplastic Humans Lymphoid Enhancer-Binding Factor 1 Multienzyme Complexes (metabolism) NF-kappa B (metabolism) Neoplasms (metabolism) Proteasome Endopeptidase Complex Proto-Oncogene Mas RNA, Messenger (metabolism) Signal Transduction Trans-Activators (metabolism) Transcription Factors (metabolism) Transforming Growth Factor beta (metabolism) Ubiquitin (metabolism) beta Catenin

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