Abstract | OBJECTIVE: METHODS: RESULTS: The frequency of loss of the expression of DPC4 protein was 32.8% in BTCa, 47.3% in CBD carcinoma, 11% in gallbladder carcinoma, 13% in HBD carcinoma. Comparison of the frequency of loss expression of DPC4 was significant statistical difference in CBD carcinoma versus gallbladder carcinoma and HBD carcinoma (P < 0.01). The frequency of loss expression of DPC4 was 48.1% in the M(+) group and 45.4% in the M(-) group. CONCLUSION: There are a close relationship between pathogenesis of BTCa and inactivation of DPC4 and different frequencies of DPC4 gene alternation in various locations of the biliary tract, which are not significantly increased with tumor metastasis in BTCa.
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Authors | Zhaohui Tang, Shengquan Zou, Youhua Hao, Baoju Wang, Xiangping Yang, Fazu Qiu |
Journal | Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
(Zhonghua Yu Fang Yi Xue Za Zhi)
Vol. 36
Issue 7
Pg. 481-4
(Dec 2002)
ISSN: 0253-9624 [Print] China |
PMID | 12411149
(Publication Type: Journal Article)
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Chemical References |
- DNA-Binding Proteins
- Smad4 Protein
- Trans-Activators
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Topics |
- Bile Duct Neoplasms
- Biliary Tract
- Carcinoma
- DNA-Binding Proteins
(metabolism)
- Humans
- Pancreatic Neoplasms
- Smad4 Protein
- Trans-Activators
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