Abstract | OBJECTIVE: STUDY DESIGN: RESULTS: There was a significant correlation between serum CA 125 and N -acetylglucosamine:beta1,4- galactosyltransferase levels before the operation (r = 0.57; P =.03) but not before second-look surgery (r = 0.10; P =.57). Thirteen patients (39.4%) had residual disease at second-look surgery. Elevated N-acetylglucosamine:beta-1,4galactosyltransferase activity >22,000 cpm correctly identified 10 of these patients (76.9%). The sensitivity, specificity, and positive and negative predictive values of N-acetylglucosamine:beta1,4- galactosyltransferase activity (>22,000 counts/min) for the prediction of residual disease at second-look surgery were 77%, 45%, 48%, and 77%, respectively. CONCLUSION:
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Authors | Kunle Odunsi, Sharad Ghamande, E V Chandrasekaran, Alyssa Ta, Kirsten B Moysich, Deborah Driscoll, Khushi Matta, Shashikant Lele |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 187
Issue 3
Pg. 575-80
(Sep 2002)
ISSN: 0002-9378 [Print] United States |
PMID | 12237630
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- CA-125 Antigen
- N-Acetyllactosamine Synthase
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Topics |
- Adult
- Aged
- Biomarkers, Tumor
(blood)
- CA-125 Antigen
(blood)
- Female
- Humans
- Middle Aged
- N-Acetyllactosamine Synthase
(blood)
- Neoplasm, Residual
- Neoplasms, Glandular and Epithelial
(blood, therapy)
- Ovarian Neoplasms
(blood, therapy)
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