CA-125 Antigen (CA 125 Antigen)

A carbohydrate antigen that occurs in tumors of the ovary as well as in breast, kidney, and gastrointestinal tract tumors and normal tissue. While it is tumor-associated, it is not tumor-specific and may have a protective function against particles and infectious agents at mucosal surfaces.

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Networked: 411 relevant articles (11 outcomes, 45 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Markman, Maurie: 8 articles (03/2011 - 07/2003)
2.	Liang, Zhijian: 4 articles (05/2019 - 01/2015)
3.	Konstantopoulos, Konstantinos: 4 articles (09/2015 - 03/2012)
4.	Wang, Wei: 3 articles (05/2021 - 03/2016)
5.	Takano, Masashi: 3 articles (04/2021 - 08/2010)
6.	Chen, Li: 3 articles (09/2020 - 01/2018)
7.	Huang, Gelun: 3 articles (05/2019 - 05/2017)
8.	Lu, Qiuhong: 3 articles (05/2019 - 05/2017)
9.	Chen, Shih-Hsun: 3 articles (01/2013 - 03/2012)
10.	Coester, Annemieke M: 3 articles (11/2011 - 12/2007)

Related Diseases

1.	Neoplasms (Cancer) 02/01/1995 - "We compared the improved Abbott IMx cancer antigen (CA) 125 assay (cat. " 07/01/2023 - "In this study, we attempted to validate various RMIs with the help of menopausal status, ultrasonogram score, cancer antigen (CA) 125 value and compare all four RMIs, which would be useful to differentiate benign and malignant ovarian masses. " 01/01/2009 - "The aim of this study was to assess the prognostic value of cancer antigen (CA) 125 and CA 72-4 in patients with ovarian borderline tumor (BOT). " 07/01/2006 - "This study also evaluated whether optimism predicted a decrease in cancer antigen (CA) 125 levels during treatment. " 11/03/2023 - "It is known that the mucin 16 (MUC16) mutation is the most common and affects the progression and prognosis of several cancers. "
2.	Ovarian Neoplasms (Ovarian Cancer) 09/01/1998 - "A pharmacokinetic analysis indicated a shorter residence time and higher clearance of (99m)Tc-MAb-B43.13 that was ascribed in part to the circulating CA 125 antigen in this group of ovarian cancer patients. " 01/01/1997 - "Two ovarian cancer cell lines, OVC432 and the newly established CVU4I, were used to study the effect of Taxal on cell growth and simultaneous CA 125 antigen expression. " 09/01/2021 - "However, the ovarian cancer antigen (CA 125) level was elevated. " 01/01/2019 - "A Mucin 16 bispecific T cell-engaging antibody for the treatment of ovarian cancer." 07/01/2017 - "In this research, ZnO nanorods - Au nanoparticles nanohybrids have been fabricated and employed to sensitive electrochemical strategy for the specific detection of the ovarian cancer antigen CA-125/MUC126. "
3.	Carcinoma (Carcinomatosis) 08/01/1990 - "Evaluation of combined TPA and CA 125 antigen results revealed a remarkable improvement in the positivity rate and a significant decrease (P less than 0.05) in the negativity rate of ovarian carcinomas as compared with the result of each one separately. " 08/01/1990 - "These findings provide complementary evidence for the previous results on the plasma levels of TPA and CA 125 antigen and suggest that specific combinations of tumour markers may be more effective for the diagnosis and monitoring of ovarian carcinomas, than the use of any single marker." 05/01/2004 - "The tumour associated CA-125 antigen is widely used in monitoring ovarian carcinoma. " 08/01/2002 - "CA 125 antigen was the most sensitive marker for ovarian carcinoma (81%). " 01/01/2002 - "Evaluation of serum levels of CA 125 antigen has been considered as useful in diagnosis and monitoring of some ovarian carcinomas. "
4.	Ovarian Epithelial Carcinoma 02/26/2022 - "Measurement of serum CA125, an antigenic fragment of human mucin 16 (MUC16), is used to monitor the clinical progression of epithelial ovarian cancer (EOC). " 04/01/2009 - "There are limited data regarding unique clinical or laboratory features associated with advanced clear cell (CC) and mucinous (MU) epithelial ovarian cancers (EOC), particularly the relationship between CA-125 antigen levels and prognosis. " 12/01/1986 - "Characterization of the CA 125 antigen associated with human epithelial ovarian carcinomas." 05/01/1985 - "The serum levels of antigen CA 125 expressed by epithelial ovarian carcinoma were measured in 27 postmenopausal women with ovarian tumours and in 16 controls. " 06/01/2005 - "Among patients with epithelial ovarian cancer in whom initial treatment achieved remission between April 1998 and December 2003, those patients in whom the cancer-related antigen (CA)125 level was increased during the subsequent follow-up period, or those who showed abnormal computed tomography (CT)/magnetic resonance imaging (MRI) findings despite normal CA125 levels, were examined by 18F-fluoro-2-deoxyglucose - positron emission tomography (FDG-PET). "
5.	Endometriosis 02/01/2015 - "Preoperative serum CA-125 antigen levels were evaluated by electrochemoluminescence immunoassay in women with endometriosis and controls. " 05/01/1989 - "Serum CA 125 antigen levels and disease severity in patients with endometriosis." 01/01/1987 - "Serum CA-125 antigen levels were measured by radioimmunoassay before and during menses in women with and without endometriosis. " 01/01/1987 - "CA 125 antigen is an effective diagnostic for external endometriosis." 11/01/1986 - "CA-125 antigen in rhesus monkeys with spontaneous endometriosis."

Related Drugs and Biologics

1.	Antigens
2.	Tumor Biomarkers (Tumor Markers)
3.	Carcinoembryonic Antigen
4.	Proteins (Proteins, Gene)
5.	Monoclonal Antibodies
6.	Enzymes
7.	alpha Subunit Glycoprotein Hormones
8.	Fetal Proteins (Fetoprotein)
9.	Drug Implants
10.	human KLK3 protein

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Drug Therapy (Chemotherapy)
3.	Therapeutics
4.	Immunotherapy
5.	Intrauterine Devices (Intrauterine Device)