[A clinical research on oxymatrine for the treatment of chronic hepatitis B].

Abstract

OBJECTIVE:

To investigate the clinical effect of oxymatrine on chronic viral hepatitis B and to look for new methods for treating hepatitis B.

METHODS:

Multi-center, controlled study was used. In this study, 196 patients were allocated to oxymatrine, oxymatrine with Ara-AMP, IFN-a1b, and glucose groups to observe ALT, AST and viral marker changes.

RESULTS:

At the end of treatment, the rate of normal ALT, the negative rate of HBV DNA and HBeAg, and the positive rate of HBeAb were similar in oxymatrine, oxymatrine with Ara-AMP, and IFN-a1b groups. It was higher than that of glucose group. After 12 months follow up, the total effective rate is 40.8%, 60.8% and 43.1% in oxymatrine, oxymatrine with Ara-AMP, and IFN-a1b groups, respectively.

CONCLUSIONS:

Oxymatrine, oxymatrine with Ara-AMP, and IFN-a1b are effective to treat hepatitis B with a good negative rate of HBV DNA and HBeAg and positive rate of HBeAb.

• Authors: Yan Yan Yu, Qin Huan Wang, Li Min Zhu, Qing Bo Zhang, Dao Zhen Xu, Yan Bin Guo, Chao Quan Wang, Shu Hua Guo, Xia Qiu Zhou, Ling Xia Zhang
• Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology (Zhonghua Gan Zang Bing Za Zhi) Vol. 10 Issue 4 Pg. 280-1 (Aug 2002) ISSN: 1007-3418 [Print] China
• PMID: 12223140 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Multicenter Study)

Chemical References

• Alkaloids
• Antiviral Agents
• Quinolizines
• oxymatrine

Topics

• Adolescent
• Adult
• Alkaloids (adverse effects, therapeutic use)
• Antiviral Agents (therapeutic use)
• Female
• Hepatitis B, Chronic (drug therapy)
• Humans
• Male
• Middle Aged
• Quinolizines