Abstract | OBJECTIVE: METHODS: One hundred fifty-seven patients with aPL antibodies were studied. The occurrence of venous and arterial thrombotic events since the time of antibody detection was determined retrospectively, using appropriate clinical and diagnostic criteria. Clinical risk factors for thrombosis were documented and included hypertension, hyperlipidemia, cigarette smoking, diabetes, positive family history, use of oral contraceptive, pregnancy, trauma, hospitalization, varicose veins, and malignancy. Genomic DNA was extracted from blood cells for determination of factor V Leiden mutation G1691 --> A and prothrombin mutation G20210 --> A by polymerase chain reaction and restriction fragment length polymorphism analysis. RESULTS: CONCLUSION: Although the prevalence of factor V Leiden is modestly increased in patients with autoimmune aPL antibodies and thrombosis, these results suggest that its detection does not significantly increase the risk of a thrombotic event, once other clinical risk factors have been considered. Prothrombin gene mutation is not associated with thrombosis in patients with aPL antibodies.
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Authors | Nikhil Chopra, Sharon Koren, Wenda L Greer, Paul R Fortin, Joyce Rauch, Isabelle Fortin, Jean-Luc Senécal, Peter Docherty, John G Hanly |
Journal | The Journal of rheumatology
(J Rheumatol)
Vol. 29
Issue 8
Pg. 1683-8
(Aug 2002)
ISSN: 0315-162X [Print] Canada |
PMID | 12180730
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Antiphospholipid
- factor V Leiden
- Factor V
- Prothrombin
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antibodies, Antiphospholipid
(blood)
- Antiphospholipid Syndrome
(blood, complications, genetics)
- DNA Mutational Analysis
- Factor V
(analysis, genetics)
- Female
- Humans
- Male
- Middle Aged
- Point Mutation
- Polymerase Chain Reaction
- Prothrombin
(analysis, genetics)
- Risk Factors
- Thrombosis
(blood, complications, genetics)
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