[Effect of Epitalon and Vilon treatment on mammary carcinogenesis in transgenic erbB-2/NEU mice].
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| Abstract |
Female transgenic FVB mice transfected with the mammary erbB-2/neu oncogene were injected 0.1 ml 0.9% solution of sodium chloride (control), 1 meg Vilon peptide (Lys-Glu) or Epitalon peptide (Ala-Glu-Asp-Glu), s.c., 5 days in succession once a month, beginning from the age of 2 months. The characteristics of mammary tumor induction in the control and experimental groups did not differ until the age of 9 months. Later on, Epitalon-treated mice revealed distinct inhibition of carcinogenesis. One tumor per animal was detected in 7% (control), 4% (Vilon) and 16% (Epitalon) (p < 0.05). Two or more tumors per animal were in 75%, 95% and 56%, respectively (p < 0.05). Largest diameter of mammary adenocarcinoma in the Epitalon group was smaller than in controls by 33% (p < 0.05). Although the number of mice with metastases to the lung in all three groups was practically identical, their incidence in the Vilon group was 2.6 times higher than in Epitalon-treated animals (p < 0.05). Largest diameter of metastasis in the Epitalon group was the smallest, too. Our data point to inhibition of mammary carcinogenesis by Epitalon in transgenic erbB-2/neu mice.
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| Authors | I N Alimova, D A Bashurin, I G Popovich, M A Zabezhinskiĭ, M A Volkov, M Provinciali, C Franceschi, B Kh Khavincon, V N Anisimov |
| Journal | Voprosy onkologii (Vopr Onkol) Vol. 48 Issue 1 Pg. 57-60 ( 2002) ISSN: 0507-3758 [Print] Russia (Federation) |
| Vernacular Title | Vliianie épitalona i vilona na prodolzhitel'nost' zhizni i razvitie opukholeĭ molochnoĭ zhelezy u samok transgennykh misheĭ erB-2/neu. |
| PMID | 12101568 (Publication Type: Journal Article) |
| Chemical References |
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