Abstract | BACKGROUND/AIMS: Autodigestion and impairment of microcirculation of the pancreas play an important role in the pathogenesis of acute pancreatitis. Somatostatin with the reducing effect on the hepato-splanchnic blood flow decreases exocrine pancreatic secretion. Microcirculatory changes are central to the pathogenesis of acute pancreatitis. However, little is known about the effects of somatostatin on the pancreatic tissue oxygen pressure and acinar cell injury during acute pancreatitis. The aim was to evaluate somatostatin by measuring its effect on the pancreatic tissue oxygen pressure and acinar injury in acute pancreatitis. METHODOLOGY: RESULTS: The two study groups were comparable with regard to mean arterial pressure, heart rate, arterial blood gases, hematocrit, and serum amylase. The induction of pancreatitis resulted in the significant decrease of pancreatic tissue oxygen pressure in both groups. The use of somatostatin did not increase pancreatic tissue oxygen pressure. There were no significant differences in plasma trypsinogen activation peptide and serum amylase levels in the animals of two treatment groups. Only somatostatin decreased pancreatic damage significantly. CONCLUSIONS:
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Authors | Metin Piri, Etem Alhan, Uzer Küçüktülü, Cengiz Erçin, Orhan Deger, Kadir Yücel, Ramazan Cicek |
Journal | Hepato-gastroenterology
(Hepatogastroenterology)
2002 May-Jun
Vol. 49
Issue 45
Pg. 833-7
ISSN: 0172-6390 [Print] Greece |
PMID | 12064001
(Publication Type: Journal Article)
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Chemical References |
- Hormones
- Oligopeptides
- trypsinogen activation peptide
- Somatostatin
- Oxygen
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Topics |
- Animals
- Hormones
(pharmacology)
- Male
- Microcirculation
(drug effects)
- Oligopeptides
(blood)
- Oxygen
(metabolism)
- Pancreas
(blood supply, drug effects)
- Pancreatitis, Acute Necrotizing
(physiopathology)
- Rats
- Rats, Sprague-Dawley
- Somatostatin
(pharmacology)
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