[Disorders of lipid and glucose metabolism. Long-term adverse effects of antiretroviral therapy].

Abstract

In addition to readily controllable short-term side effects, highly active antiretroviral therapy (HAART) also has long-term side effects: lipodystrophy syndrome, hyperlipoproteinemia, insulin resistance, elevated glucose tolerance sometimes leading to diabetes mellitus and lactic acidosis. The pathogenesis remains uncertain although various hypotheses have been advanced. A number of approaches for the treatment of lipodystrophy are available, the effects of which, however, have not been confirmed by study results. Hyperlipoproteinemia probably means an increased cardiovascular risk, but a final pronouncement on this is not yet possible. Fibrates and statins are currently applied for treatment, but interactions with HAART medicaments have to be considered. HAART-induced diabetes mellitus presents clinically as type 2 diabetes, and is treated accordingly.

• Authors: N Landauer, F D Goebel
• Journal: MMW Fortschritte der Medizin (MMW Fortschr Med) Vol. 144 Suppl 1 Pg. 16-8 (Apr 09 2002) ISSN: 1438-3276 [Print] Germany
• Vernacular Title: Störungen des Lipid- und Glukosestoffwechsels. Langzeitnebenwirkungen antiretroviraler Therapie.
• PMID: 12043065 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-HIV Agents

Topics

• Acquired Immunodeficiency Syndrome (drug therapy)
• Anti-HIV Agents (adverse effects, therapeutic use)
• Antiretroviral Therapy, Highly Active (adverse effects)
• Diabetes Mellitus, Type 2 (chemically induced)
• HIV Infections (drug therapy)
• Humans
• Hyperlipoproteinemias (chemically induced)
• Lipodystrophy (chemically induced)
• Long-Term Care
• Risk Factors