Abstract | STUDY DESIGN: OBJECTIVES: SUMMARY OF BACKGROUND DATA: METHODS: Using a reverse transcription-polymerase chain reaction, mRNA expressions of cytokines and chemokines were investigated in herniated disc specimens. The straight leg raising test, development of radicular pain by back extension, symptom duration, pain intensity using a visual analogue scale, and herniation types were described. RESULTS: The mRNAs of IL-8, TNF-alpha, IL-1alpha, RANTES, and IL-10 were expressed in 16 (70%), 15 (65%), 9 (39%), 4 (17%), and 2 (9%) of the 23 herniated disc specimens, respectively. The mRNA of TGF-beta was expressed in 5 of 10 specimens (50%). IL-8 mRNA expression was associated with the development of radicular pain by back extension and short symptom duration (average 3.8 weeks). The mRNAs of IL-1alpha were expressed more frequently in transligamentous extensions than in subligamentous extensions, but the expression was weak. CONCLUSION:
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Authors | Sang-Ho Ahn, Yoon-Woo Cho, Myun-Whan Ahn, Sung-Ho Jang, Yoon-Kyung Sohn, Hee-Sun Kim |
Journal | Spine
(Spine (Phila Pa 1976))
Vol. 27
Issue 9
Pg. 911-7
(May 01 2002)
ISSN: 1528-1159 [Electronic] United States |
PMID | 11979160
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Chemokine CCL5
- Chemokines
- Cytokines
- Interleukin-1
- Interleukin-8
- RNA, Messenger
- Transforming Growth Factor beta
- Tumor Necrosis Factor-alpha
- Interleukin-10
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Topics |
- Adult
- Aged
- Back Pain
(etiology, metabolism)
- Chemokine CCL5
(genetics, metabolism)
- Chemokines
(genetics, metabolism)
- Cytokines
(genetics, metabolism)
- Female
- Humans
- Interleukin-1
(genetics, metabolism)
- Interleukin-10
(genetics, metabolism)
- Interleukin-8
(genetics, metabolism)
- Intervertebral Disc Displacement
(complications, metabolism, surgery)
- Lumbosacral Region
- Male
- Middle Aged
- Predictive Value of Tests
- RNA, Messenger
(biosynthesis)
- Reverse Transcriptase Polymerase Chain Reaction
- Transforming Growth Factor beta
(genetics, metabolism)
- Tumor Necrosis Factor-alpha
(genetics, metabolism)
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