Abstract |
The Lim domain homeobox gene (Isl-1) is a positional candidate gene for obesity that maps on chromosome 5q11-q13, a locus linked to BMI and leptin levels in French Caucasians. Isl-1 might be involved in body weight regulation and glucose homeostasis via the activation of proglucagon gene expression, which encodes for glucagon and glucagon-like peptides. By mutation screening of 72 obese subjects, we identified three single-nucleotide polymorphisms (SNPs) in the Isl1 gene. The allele frequencies in the morbidly obese group did not differ from that of the control group. In the obese group, the -47G allele was associated with a decreased risk of type 2 diabetes (odds ratio 0.41, P = 0.019). The AG bearers displayed a higher maximal BMI than the AA bearers in the whole obese group (P = 0.026) as well as in the type 2 diabetic obese subgroup (P = 0.014). In obese families, this allele was not preferentially transmitted from heterozygous parents to their obese siblings, indicating that Isl-1 does not contribute to the linkage with obesity on 5cen-q. However, in French Caucasian morbidly obese subjects, the Isl1-47A-->G SNP may modulate the risk for type 2 diabetes and may increase body weight in diabetic morbidly obese subjects.
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Authors | Mouna Barat-Houari, Karine Clément, Vincent Vatin, Christian Dina, Geneviève Bonhomme, Francis Vasseur, Bernard Guy-Grand, Philippe Froguel |
Journal | Diabetes
(Diabetes)
Vol. 51
Issue 5
Pg. 1640-3
(May 2002)
ISSN: 0012-1797 [Print] United States |
PMID | 11978668
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Homeodomain Proteins
- LIM-Homeodomain Proteins
- Nerve Tissue Proteins
- Transcription Factors
- insulin gene enhancer binding protein Isl-1
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Topics |
- Adult
- Aged
- Chromosomes, Human, Pair 5
- Diabetes Mellitus
(epidemiology, genetics)
- Diabetes Mellitus, Type 2
(epidemiology, genetics)
- Female
- France
(epidemiology)
- Genetic Linkage
- Genetic Predisposition to Disease
- Genotype
- Homeodomain Proteins
(genetics)
- Humans
- LIM-Homeodomain Proteins
- Male
- Middle Aged
- Nerve Tissue Proteins
- Obesity
- Obesity, Morbid
(epidemiology, genetics)
- Risk Factors
- Transcription Factors
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