Abstract | OBJECTIVE: DESIGN: Prospective study. SETTING: An adult trauma/surgical ICU in an urban teaching hospital. PATIENTS: INTERVENTIONS: None. MEASUREMENTS AND RESULTS:
PTHrP was detected in all BAL fluids, and ELF PTHrP concentrations (median; 25% to 75% percentiles) tended to be higher in patients (52.2 nmol/mL; 20.8 to 65.6 nmol/mL) than in control subjects (25.4 nmol/mL; 20.5 to 35.4 nmol/mL; p = 0.18). In patients, ELF PTHrP concentration correlated positively with the PaO(2)/fraction of inspired oxygen ratio (r = 0.53; p = 0.005), and negatively with lung injury score (r = - 0.44; p = 0.02), radiologic score (r = - 0.40; p = 0.04), and BAL albumin concentration (r = - 0.42; p = 0.02). CONCLUSION:
PTHrP is present in biologically significant concentrations in the alveolar milieu in humans. In patients with ALI, the PTHrP concentration correlates negatively with the degree of lung injury.
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Authors | Jean-Baptiste Stern, Oana Bernard, Catherine Paugam, Caroline Silve, Jean Mantz, Michel Aubier, Bruno Crestani |
Journal | Chest
(Chest)
Vol. 121
Issue 3
Pg. 852-7
(Mar 2002)
ISSN: 0012-3692 [Print] United States |
PMID | 11888972
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- PTHLH protein, human
- Parathyroid Hormone
- Parathyroid Hormone-Related Protein
- Proteins
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Topics |
- Acute Disease
- Adult
- Aged
- Aged, 80 and over
- Bronchoalveolar Lavage Fluid
(chemistry)
- Epithelium
- Female
- Humans
- Lung
(metabolism)
- Lung Injury
- Male
- Middle Aged
- Parathyroid Hormone
(analysis)
- Parathyroid Hormone-Related Protein
- Prospective Studies
- Proteins
(analysis)
- Pulmonary Alveoli
(cytology, pathology)
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