Genetic contribution of the interleukin-10 promoter polymorphism in endometriosis susceptibility.

Abstract

PROBLEM:

Interleukin-10 (IL-10) is an important immunomodulatory cytokine. The aim of this study was to investigate whether polymorphisms of the IL-10 gene promoter polymorphisms may be responsible in part for genetic susceptibility to endometriosis.

METHODS OF STUDY:

Polymorphisms at position -1082 and -592 in the IL-10 promoter region were determined in 196 patients with endometriosis and 160 fertile healthy women by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP).

RESULTS:

There were no statistically significant differences in the genotype and allele frequencies of IL-10 promoter polymorphism between the endometriosis and control groups. However, when subgrouped according to clinical features, the frequencies of the -592*CC genotype and -592*C allele were significantly increased in patients with autoantibodies to carbonic anhydrase II (anti-CA II ab) compared with controls.

CONCLUSION:

IL-10 promoter polymorphisms were associated with the production of anti-CA II ab in patients with endometriosis, suggesting a role in the genetic susceptibility for endometriosis.

• Authors: Jo Kitawaki, Hiroshi Obayashi, Mitsuhiro Ohta, Noriko Kado, Hiroaki Ishihara, Hisato Koshiba, Izumi Kusuki, Katsumi Tsukamoto, Goji Hasegawa, Naoto Nakamura, Toshikazu Yoshikawa, Hideo Honjo
• Journal: American journal of reproductive immunology (New York, N.Y. : 1989) (Am J Reprod Immunol) Vol. 47 Issue 1 Pg. 12-8 (Jan 2002) ISSN: 1046-7408 [Print] Denmark
• PMID: 11883743 (Publication Type: Journal Article)

Chemical References

• Autoantibodies
• Interleukin-10
• Carbonic Anhydrase II

Topics

• Adult
• Alleles
• Autoantibodies (blood)
• Carbonic Anhydrase II (immunology)
• Case-Control Studies
• Endometriosis (genetics, immunology)
• Female
• Gene Frequency
• Genotype
• Humans
• Interleukin-10 (genetics)
• Middle Aged
• Polymerase Chain Reaction
• Polymorphism, Genetic
• Polymorphism, Restriction Fragment Length
• Promoter Regions, Genetic