Abstract | OBJECTIVE:
Insulin resistance and its compensatory hyperinsulinemia play a key pathogenic role in the infertility of the polycystic ovary syndrome. Numerous studies indicate that insulin-sensitizing drugs can be used to enhance spontaneous ovulation and the induction of ovulation in the syndrome. The aim of this review is to summarize the studies in which insulin-sensitizing drugs were used to increase ovulation rate or improve fertility in women with the PCOS and to translate the information into practical guidelines for the use of these drugs by reproductive endocrinologists. DESIGN: MAIN OUTCOME MEASURE(S): Ovulation rate and pregnancy rate. RESULT(S): Studies have demonstrated that insulin-sensitizing drugs can increase spontaneous ovulation, enhance the induction of ovulation with clomiphene citrate, and increase clinical pregnancy rates. CONCLUSION(S):
|
Authors | John E Nestler, Dale Stovall, Nausheen Akhter, Maria J Iuorno, Daniela J Jakubowicz |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 77
Issue 2
Pg. 209-15
(Feb 2002)
ISSN: 0015-0282 [Print] United States |
PMID | 11821072
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S., Review)
|
Chemical References |
- Fertility Agents, Female
- Hypoglycemic Agents
- Clomiphene
- Metformin
|
Topics |
- Algorithms
- Clomiphene
(therapeutic use)
- Female
- Fertility Agents, Female
(therapeutic use)
- Humans
- Hypoglycemic Agents
(administration & dosage, therapeutic use)
- Infertility, Female
(complications, drug therapy, pathology)
- Insulin Resistance
(physiology)
- Metformin
(administration & dosage, therapeutic use)
- Ovulation Induction
(methods)
- Polycystic Ovary Syndrome
(complications, pathology)
- Pregnancy
|