Abstract |
Studies on serologic correlates to protection in pertussis were reviewed. Trials in the 1950s showed that agglutinogen titers correlated to protection of whole-cell vaccines, but postvaccination antibodies against pertussis toxin (PT) and against filamentous hemagglutinin did not in a later trial of acellular vaccines. However, in household studies nested in 2 recent trials, preexposure antibody levels against pertactin and against fimbriae correlated with protection against typical and mild pertussis, and anti-PT correlated only with protection against typical pertussis. These findings could be used by regulatory agencies to license pertussis vaccines. A reference laboratory for pertussis should distribute panels to control interlaboratory variation in recommended assays, and a minimal response should be set for each pertussis antigen. We conclude that 2 studies have shown correlates between measurable anti- pertactin, anti-fimbriae, and anti-PT antibody levels at exposure and individual protection against pertussis. We suggest that postvaccination response rates may be used as surrogate markers of protection.
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Authors | P Olin, H O Hallander, L Gustafsson, E Reizenstein, J Storsaeter |
Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
(Clin Infect Dis)
Vol. 33 Suppl 4
Pg. S288-91
(Dec 15 2001)
ISSN: 1058-4838 [Print] United States |
PMID | 11709761
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S., Review)
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Chemical References |
- Antibodies, Bacterial
- Antigens, Bacterial
- Bacterial Outer Membrane Proteins
- Biomarkers
- Pertussis Vaccine
- Virulence Factors, Bordetella
- pertactin
- Pertussis Toxin
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Topics |
- Antibodies, Bacterial
(blood)
- Antigens, Bacterial
(immunology)
- Bacterial Outer Membrane Proteins
(immunology)
- Biomarkers
(blood)
- Case-Control Studies
- Clinical Trials as Topic
- Fimbriae, Bacterial
(immunology)
- Humans
- Pertussis Toxin
- Pertussis Vaccine
(immunology)
- Reference Standards
- Virulence Factors, Bordetella
(immunology)
- Whooping Cough
(immunology, prevention & control)
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