HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

How to make sense of pertussis immunogenicity data.

Abstract
Studies on serologic correlates to protection in pertussis were reviewed. Trials in the 1950s showed that agglutinogen titers correlated to protection of whole-cell vaccines, but postvaccination antibodies against pertussis toxin (PT) and against filamentous hemagglutinin did not in a later trial of acellular vaccines. However, in household studies nested in 2 recent trials, preexposure antibody levels against pertactin and against fimbriae correlated with protection against typical and mild pertussis, and anti-PT correlated only with protection against typical pertussis. These findings could be used by regulatory agencies to license pertussis vaccines. A reference laboratory for pertussis should distribute panels to control interlaboratory variation in recommended assays, and a minimal response should be set for each pertussis antigen. We conclude that 2 studies have shown correlates between measurable anti-pertactin, anti-fimbriae, and anti-PT antibody levels at exposure and individual protection against pertussis. We suggest that postvaccination response rates may be used as surrogate markers of protection.
AuthorsP Olin, H O Hallander, L Gustafsson, E Reizenstein, J Storsaeter
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 33 Suppl 4 Pg. S288-91 (Dec 15 2001) ISSN: 1058-4838 [Print] United States
PMID11709761 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S., Review)
Chemical References
  • Antibodies, Bacterial
  • Antigens, Bacterial
  • Bacterial Outer Membrane Proteins
  • Biomarkers
  • Pertussis Vaccine
  • Virulence Factors, Bordetella
  • pertactin
  • Pertussis Toxin
Topics
  • Antibodies, Bacterial (blood)
  • Antigens, Bacterial (immunology)
  • Bacterial Outer Membrane Proteins (immunology)
  • Biomarkers (blood)
  • Case-Control Studies
  • Clinical Trials as Topic
  • Fimbriae, Bacterial (immunology)
  • Humans
  • Pertussis Toxin
  • Pertussis Vaccine (immunology)
  • Reference Standards
  • Virulence Factors, Bordetella (immunology)
  • Whooping Cough (immunology, prevention & control)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: