Abstract | OBJECTIVE: METHODS: RESULTS: Nodal micrometastasis was detected in 44 patients. The mean tumor sizes were 2.2 +/- 1.3 cm (range, 1.0-7.0 cm) in nodal micrometastasis-positive adenocarcinoma, 2.1 +/- 0.9 cm (range, 0.5-6.0 cm) in nodal micrometastasis-negative adenocarcinoma, 4.8 +/- 2.3 cm (range, 2.2-10.0 cm) in nodal micrometastasis-positive squamous cell carcinoma, and 3.2 +/- 2.1 cm (range, 0-9.0 cm) in nodal micrometastasis-negative squamous cell carcinoma. The tumor size in the nodal micrometastasis-positive group tended to be greater than that in the nodal micrometastasis-negative group in squamous cell carcinomas, but there was no significant difference in adenocarcinomas. Nodal micrometastasis was not found in patients with squamous cell carcinoma of 2.0 cm or less in diameter. However, nodal micrometastasis was found in 20% (19/95) of the patients with adenocarcinoma of 1.1 to 2.0 cm in diameter and even in 4 of 11 patients with adenocarcinoma of 1.0 cm or less. Among the patients with nodal micrometastasis, survival of patients with vascular endothelial growth factor overexpression was worse than that of patients without it. The survival of patients with nodal micrometastasis without vascular endothelial growth factor overexpression was comparable with that of patients without nodal micrometastasis. CONCLUSION:
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Authors | Y Ohta, M Oda, J Wu, Y Tsunezuka, M Hiroshi, A Nonomura, G Watanabe |
Journal | The Journal of thoracic and cardiovascular surgery
(J Thorac Cardiovasc Surg)
Vol. 122
Issue 5
Pg. 900-6
(Nov 2001)
ISSN: 0022-5223 [Print] United States |
PMID | 11689794
(Publication Type: Journal Article)
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Chemical References |
- Endothelial Growth Factors
- Lymphokines
- Protein Isoforms
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
- Keratins
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Topics |
- Adenocarcinoma
(mortality, pathology, surgery)
- Carcinoma, Non-Small-Cell Lung
(mortality, pathology, surgery)
- Carcinoma, Squamous Cell
(mortality, pathology, surgery)
- Endothelial Growth Factors
(metabolism)
- Female
- Follow-Up Studies
- Humans
- Keratins
(metabolism)
- Lung Neoplasms
(mortality, pathology, surgery)
- Lymph Node Excision
- Lymph Nodes
(metabolism, pathology)
- Lymphatic Metastasis
- Lymphokines
(metabolism)
- Male
- Middle Aged
- Protein Isoforms
- Time Factors
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
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