Effect of food reductones, 2,5-dimethyl-4-hydroxy-3(2H)-furanone (DMHF) and hydroxyhydroquinone (HHQ), on lipid peroxidation and type IV and I allergy responses of mouse.

Abstract

The effect of long-term supplementation of food reductones, 2,5-dimethyl-4-hydroxy-3(2H)-furanone (DMHF) (2%, w/w), detected in many foodstuffs including soy sauce, and hydroxyhydroquinone (1,2,4-benzenetriol) (HHQ) (1.2%, w/w), detected in coffee, on mouse lipid peroxidation and type IV and I allergy responses was investigated. The effect of supplementation of these reductones combined with NO(2) inhalation (5-6 ppm) was also investigated. Levels of thiobarbituric acid-reactive substances in lung were remarkably increased, and those in kidney and liver were slightly decreased by supplementation of DMHF or HHQ. The degree of 2,4-dinitrochlorobenzene (DNCB)-sensitized lymph node cell proliferation as assessed by lymph node assay was remarkably enhanced by supplementation of DMHF or HHQ. Both the DNCB-sensitized and the trimellitic anhydride-sensitized increases in IgE levels of mice were enhanced to greater extent by supplementation of DMHF or HHQ. In no cases were additive effects of NO(2) inhalation observable. Allergen-sensitized type IV and I allergy responses of mice may be enhanced by supplementation of food reductones, DMHF or HHQ.

• Authors: H Mi, K Hiramoto, K Kujirai, K Ando, Y Ikarashi, K Kikugawa
• Journal: Journal of agricultural and food chemistry (J Agric Food Chem) Vol. 49 Issue 10 Pg. 4950-5 (Oct 2001) ISSN: 0021-8561 [Print] United States
• PMID: 11600049 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Coffee
• Dinitrochlorobenzene
• Furans
• Hydroquinones
• Phthalic Anhydrides
• Thiobarbituric Acid Reactive Substances
• hydroxyhydroquinone
• furaneol
• Immunoglobulin E
• trimellitic anhydride
• Nitrogen Dioxide

Topics

• Animals
• Coffee (chemistry)
• Dermatitis, Contact (etiology)
• Diet
• Dinitrochlorobenzene (immunology)
• Food Analysis
• Furans (administration & dosage, adverse effects)
• Hydroquinones (administration & dosage, adverse effects)
• Immunoglobulin E (blood)
• Lipid Peroxidation (drug effects)
• Lymph Nodes (immunology)
• Male
• Mice
• Mice, Inbred BALB C
• Nitrogen Dioxide (administration & dosage)
• Phthalic Anhydrides (immunology)
• Respiratory Hypersensitivity (etiology)
• Soybeans (chemistry)
• Thiobarbituric Acid Reactive Substances (analysis)