[Influence of N-palmitoylethanolamine on the phospholipid and fatty acid composition of rat liver in ischemia].

Abstract

The effect of N-palmitoylethanolamine (NPE, 10(-5) M) on the lipid peroxidation (LPO) processes, phospholipid and fatty acid content in the rat liver at perfusion and ischemia during the liver preservation was estimated. As early as at the 5th min of perfusion by cooled conserving solution "Eurocollins", LPO activation was determined. Simultaneously the content of lysophosphatidylcholine (LPC) and phosphatidylserine increased, the total cholesterol level decreased. The redistribution of saturated and unsaturated fatty acids quantity was detected. The addition of NPE into "Eurocollins" solution reduced the accumulation of malonedialdehyde and LPC, modified the fatty acids content. These effects, evidently, formed the basis of the protective action of NPE on the hepatic tissues under anoxia.

• Authors: T M Gorid'ko, N M Hula, V M Marhitych, N M Hovseieva, V M Klimashevs'kyĭ, M Iu Shahidulin
• Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) (Ukr Biokhim Zh (1999)) 2001 Jan-Feb Vol. 73 Issue 1 Pg. 82-7 Ukraine
• Vernacular Title: Vyvchennia vplyvu N-pal'mitoïletanolaminu na sklad fosfolipidiv ta zhyrnykh kyslot pechinky shchuriv za ishemiï
• PMID: 11599433 (Publication Type: Journal Article)

Chemical References

• Amides
• Endocannabinoids
• Ethanolamines
• Fatty Acids
• Palmitic Acids
• Phospholipids
• Malondialdehyde
• palmidrol

Topics

• Amides
• Animals
• Endocannabinoids
• Ethanolamines
• Fatty Acids (metabolism)
• Ischemia (metabolism)
• Lipid Peroxidation
• Liver (blood supply, drug effects, metabolism)
• Male
• Malondialdehyde (metabolism)
• Palmitic Acids (pharmacology)
• Phospholipids (metabolism)
• Rats