Abstract | BACKGROUND: METHODS: A retrospective study of a cohort of 110 patients diagnosed between 1989 and 1996 with a locally advanced laryngeal carcinoma (T3-T4) treated with induction chemotherapy and radiotherapy was performed. The results of salvage surgery in patients with a local and/or regional failure of the treatment were analyzed. RESULTS: Forty-two patients presented a local and/or a regional recurrence of the tumor: 26 patients in the larynx, eight in the neck, and a further eight in both in the larynx and the neck. Salvage surgery was carried out in 28 patients (67%), consisting of total laryngectomies with neck dissections (24 cases), endoscopic resection of the tumor (one case), and radical neck dissections (three cases). Five-year adjusted survival for the 42 patients was 38%. Five-year survival for the 28 patients treated with salvage surgery was 57%. Five patients had postoperative complications: four had pharyngo- cutaneous fistulas and one had wound infection. CONCLUSIONS: After a local and/or regional recurrence, 67% of patients with advanced laryngeal carcinoma treated with induction chemotherapy and radiotherapy were candidates to salvage surgery. Five-year adjusted survival for this group of patients was 57%.
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Authors | X León, M Quer, C Orús, M López, J R Gras, M Vega |
Journal | Head & neck
(Head Neck)
Vol. 23
Issue 9
Pg. 733-8
(Sep 2001)
ISSN: 1043-3074 [Print] United States |
PMID | 11505482
(Publication Type: Journal Article)
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Copyright | Copyright 2001 John Wiley & Sons, Inc. |
Topics |
- Cohort Studies
- Combined Modality Therapy
- Humans
- Laryngeal Neoplasms
(drug therapy, radiotherapy, surgery)
- Neoplasm Recurrence, Local
(surgery)
- Postoperative Complications
- Retrospective Studies
- Salvage Therapy
(adverse effects, statistics & numerical data)
- Survival Analysis
- Treatment Outcome
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