Radioguided-surgery of early breast lesions.

Abstract

BACKGROUND:

Radioguided-surgery has been recently proposed in patients with clinically occult breast lesions. This study aimed to evaluate the feasibility of correctly locating and eradicating, by a single intralesional injection of a radiotracer, any breast lesion and, in the case of malignancy, to perform simultaneous sentinel lymph node (SLN) biopsy procedure.

PATIENTS AND METHODS:

Sixty-three women with early breast lesions were enrolled: 42 were invasive carcinomas, 16 in situ ductal carcinomas (DCIS) and 5 fibroadenomas.

RESULTS:

Scintigraphic images clearly identified the lesions in all patients while SLN/s were evident in 88% of them. At surgery all the breast lesions were easily radiolocalized and eradicated with minimum surgical trauma and, for those patients with invasive carcinomas, the SLN technique was performed in 86% of them. No skip metastases were found.

CONCLUSION:

A single intralesional administration of radiotracer is an easy and reliable procedure to simultaneously locate and remove both the non-palpable breast lesion and the SLN when primary malignancy was intraoperatively confirmed.

• Authors: O Buonomo, A Cabassi, F Guadagni, A Piazza, A Felici, R Piccirillo, G P Atzei, C Cipriani, S Schiaroli, S Mariotti, M N Guazzaroni, E Cossu, G Simonetti, E Pernazza, C U Casciani, M Roselli
• Journal: Anticancer research (Anticancer Res) 2001 May-Jun Vol. 21 Issue 3C Pg. 2091-7 ISSN: 0250-7005 [Print] Greece
• PMID: 11501831 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Radiopharmaceuticals
• Technetium Tc 99m Aggregated Albumin
• technetium Tc 99m nanocolloid

Topics

• Adult
• Aged
• Breast Neoplasms (diagnostic imaging, surgery)
• Female
• Humans
• Injections, Intralesional
• Lymph Nodes (surgery)
• Mastectomy, Segmental (methods)
• Middle Aged
• Radionuclide Imaging
• Radiopharmaceuticals (therapeutic use)
• Sentinel Lymph Node Biopsy
• Technetium Tc 99m Aggregated Albumin (therapeutic use)