Abstract | BACKGROUND:
Ulcerative colitis patients are at increased risk for developing colorectal carcinomas. Despite expensive surveillance programmes, clinical practice reflects an uncertainty in individual risk assessment. The aim of the study was to evaluate independent cellular features with possible predictive value. METHODS: RESULTS: Mild or moderate inflammatory activity was present in 78% of all biopsies, low- or high-grade dysplasia in 5.5%. There was no difference in inflammatory activity and dysplasia between patient groups. In group A, 75% of the biopsies exhibited aneuploid DNA distribution patterns. Group B showed mainly proliferative-diploid cell populations (85% / P = 0.006). Laminin-5 gamma2 chain was expressed in 13% of all biopsies, with a higher frequency in group A (P = 0.002). Cyclin A expression was found in 98% of all biopsies, with a higher number of immunopositive cells in group A biopsies (P = 0.014). CONCLUSIONS:
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Authors | J Habermann, C Lenander, U J Roblick, S Krüger, D Ludwig, A Alaiya, S Freitag, L Dümbgen, H P Bruch, E Stange, S Salo, K Tryggvason, G Auer, H Schimmelpenning |
Journal | Scandinavian journal of gastroenterology
(Scand J Gastroenterol)
Vol. 36
Issue 7
Pg. 751-8
(Jul 2001)
ISSN: 0036-5521 [Print] England |
PMID | 11444475
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Validation Study)
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Chemical References |
- Biomarkers, Tumor
- Cell Adhesion Molecules
- Cyclin A
- kalinin
- DNA
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Topics |
- Adult
- Aged
- Aneuploidy
- Biomarkers, Tumor
(analysis, genetics)
- Biopsy
- Cell Adhesion Molecules
(analysis, genetics)
- Cell Transformation, Neoplastic
(genetics, pathology)
- Colitis, Ulcerative
(classification, complications, genetics, pathology)
- Colorectal Neoplasms
(etiology)
- Cyclin A
(analysis, genetics)
- DNA
(analysis, genetics)
- DNA Fingerprinting
- Female
- Gene Expression Regulation, Neoplastic
(genetics)
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Predictive Value of Tests
- Retrospective Studies
- Risk Factors
- Severity of Illness Index
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