Regression of lymph node metastases by immunotherapy using autologous breast tumor-lysate pulsed dendritic cells: report of a case.

Abstract

A 50-year-old woman was diagnosed as having stage IV breast cancer with bilateral supraclavicular lymph node metastasis resistant to CAF therapy. She received immunotherapy using autologous tumor lysate-pulsed dendritic cells (DCs). Four cycles of DC injection into the right supraclavicular lymph nodes resulted in regression of bilateral supraclavicular lymphogenous metastasis. Histological studies revealed an accumulation of CD45+ T lymphcytes in the regressive lymph nodes. This case suggests that immunotherapy with DCs may be a safe and promising approach for the treatment of advanced breast cancer.

• Authors: T Kobayashi, H Shinohara, M Toyoda, S Iwamoto, N Tanigawa
• Journal: Surgery today (Surg Today) Vol. 31 Issue 6 Pg. 513-6 ( 2001) ISSN: 0941-1291 [Print] Japan
• PMID: 11428604 (Publication Type: Case Reports, Journal Article)

Chemical References

• Adjuvants, Immunologic
• Antigens, Neoplasm
• Hemocyanins
• keyhole-limpet hemocyanin

Topics

• Adjuvants, Immunologic
• Antigens, Neoplasm (administration & dosage, therapeutic use)
• Breast Neoplasms (pathology, therapy)
• Dendritic Cells
• Female
• Hemocyanins
• Humans
• Lymphatic Metastasis
• Middle Aged
• Remission Induction