The antiproliferative effect of coumarins on several cancer cell lines.

Abstract

Twenty-one coumarins were examined for their antiproliferative activity towards several cancer cell lines, namely lung carcinoma (A549), melanin pigment producing mouse melanoma (B16 melanoma 4A5), human T-cell leukemia (CCRF-HSB-2), and human gastric cancer, lymph node metastasized (TGBC11TKB). The structure-activity relationship established from the results revealed that the 6,7-dihydroxy moiety had an important role for their antiproliferative activity. Analysis of cell cycle distribution indicated that esculetin-treated cells accumulated in the G1 (at 400 microM) or in S phase (at 100 microM).

• Authors: S Kawaii, Y Tomono, K Ogawa, M Sugiura, M Yano, Y Yoshizawa
• Journal: Anticancer research (Anticancer Res) 2001 Mar-Apr Vol. 21 Issue 2A Pg. 917-23 ISSN: 0250-7005 [Print] Greece
• PMID: 11396185 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Coumarins
• DNA, Neoplasm
• Growth Inhibitors

Topics

• Antineoplastic Agents (chemistry, pharmacology)
• Apoptosis
• Cell Division (drug effects)
• Coumarins (chemistry, pharmacology)
• DNA Fragmentation
• DNA, Neoplasm (metabolism)
• Growth Inhibitors (chemistry, pharmacology)
• Humans
• Tumor Cells, Cultured