Elevated plasma stromal cell-derived factor 1 protein level in the progression of HIV type 1 infection/AIDS.
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| Abstract |
Stromal cell-derived factor 1 (SDF-1) is a unique chemokine involved in multiple organogenesis as well as in the regulation of HIV infection. Here we determined the plasma SDF-1 concentrations of 193 HIV-1-infected individuals and 154 normal Japanese volunteers by developing a highly sensitive measurement system based on time-resolved fluoroimmunoassay (SDF-1 TR-FIA). This system is also valid for the mouse model to quantitate circulating SDF-1 concentration in vivo and thereby its correlation with CXCR4 expression level on CD4(+) T cells. Interestingly, plasma SDF-1 concentrations in HIV-1-infected individuals were three times higher than those in a normal control group and plasma SDF-1 protein levels showed an inverse correlation with CD4(+) T cell count and a positive correlation with plasma HIV-1 RNA load. Notably, individuals with later stage HIV-1 infection, who maintained fewer than 200 CD4(+) T cells per cubic milliliter and more than 10,000 copies of HIV-1 RNA per milliliter, showed the highest plasma SDF-1 level among individuals at any stage of HIV-1 infection. These results suggest that endogenous SDF-1 is upregulated by HIV-1 infection, particularly in late-stage HIV-1 infection/AIDS.
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| Authors | M Ikegawa, J Yuan, K Matsumoto, S Herrmann, A Iwamoto, T Nakamura, S Matsushita, T Kimura, T Honjo, K Tashiro |
| Journal | AIDS research and human retroviruses (AIDS Res Hum Retroviruses) Vol. 17 Issue 7 Pg. 587-95 (May 01 2001) ISSN: 0889-2229 [Print] United States |
| PMID | 11375054 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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