Abstract |
A high-performance liquid chromatographic procedure for the quantitation of [(123)I] Iodomethyl-N,N-diethyltamoxifen (ITX), a radioligand for human breast cancer imaging, in human plasma is described. Separation was effected on a RP-C18 column, using a mixture of acetonitrile-water- triethylamine (70/30/0.5, v/v). ITX was rapidly cleared from human plasma and metabolites appeared as early as 7.5 min p.i. Quantitative assessment of metabolites in plasma over time allowed recalculation of the ITX plasma time-activity curve. Implications of ITX metabolite formation for breast tumour imaging are discussed.
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Authors | F De Vos, C Van de Wiele, M Vandecapelle, R A Dierckx, G Slegers |
Journal | Nuclear medicine and biology
(Nucl Med Biol)
Vol. 28
Issue 3
Pg. 335-8
(Apr 2001)
ISSN: 0969-8051 [Print] United States |
PMID | 11323246
(Publication Type: Journal Article)
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Chemical References |
- Anticarcinogenic Agents
- Iodine Radioisotopes
- Tamoxifen
- iodomethyl-N,N-diethyltamoxifen
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Topics |
- Aged
- Anticarcinogenic Agents
(blood, metabolism)
- Chromatography, High Pressure Liquid
- Female
- Humans
- Injections, Intravenous
- Iodine Radioisotopes
(blood, metabolism, pharmacokinetics)
- Middle Aged
- Tamoxifen
(analogs & derivatives, blood, metabolism, pharmacokinetics)
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