Close relation of fasting insulin-like growth factor binding protein-1 (IGFBP-1) with glucose tolerance and cardiovascular risk in two populations.

Abstract

AIMS/HYPOTHESIS:

Insulin resistance/hyperinsulinaemia is implicated in the development of cardiovascular disease and diabetes but its role and causal pathways are not clear. We tested the hypothesis that the insulin-like growth factor system is independently associated with cardiovascular risk within susceptible populations based on previous reports of the links between low circulating insulin-like growth factor binding protein-1 concentrations and increased macrovascular disease in Type II (non-insulin-dependent) diabetes mellitus.

METHODS:

In a population-based study 272 subjects (142 subjects of European and 130 Pakistani of origin) underwent a 75 g oral glucose tolerance test and standardised anthropometry. Fasting concentrations of insulin-like growth factor binding protein-1 (IGFBP-1), insulin-like growth factor-I (IGF-I), insulin-like growth factor-II (IGF-II), intact insulin and lipids were measured and were related to 2-h glucose tolerance test status. Insulin sensitivity was calculated using the homeostasis model assessment (HOMA).

RESULTS:

Insulin-like growth factor binding protein-1 was significantly lower in subjects with impaired glucose tolerance when compared with normal glucose tolerance in both ethnic groups (Europeans F = 6.7, p = 0.002 and Pakistanis F = 4.4, p = 0.01). Multiple linear regression modelling showed that insulin-like growth factor binding protein-1 was independently associated with 2-h glucose (beta = 0.16, p = 0.009) and logistic regression indicated a 40% reduction in risk of impaired glucose tolerance for every 2.7 ng/ml increase in the insulin-like growth factor binding protein-1 concentration [odds ratio 0.6 (CI = 0.49-0.71), p = 0.001)]. In addition, insulin-like growth factor binding protein-1 was significantly correlated negatively with several established cardiovascular factors, and positively with insulin sensitivity.

CONCLUSIONS/INTERPRETATION:

Insulin-like growth factor binding protein-1 is closely related to risk factors for diabetes and cardiovascular disease in people of European and Pakistani origin. It has potential use as a marker of (hepatic) insulin resistance in clinical intervention studies and further implicates the insulin-like growth factor system in the development of macrovascular disease.

• Authors: A H Heald, J K Cruickshank, L K Riste, J E Cade, S Anderson, A Greenhalgh, J Sampayo, W Taylor, W Fraser, A White, J M Gibson
• Journal: Diabetologia (Diabetologia) Vol. 44 Issue 3 Pg. 333-9 (Mar 2001) ISSN: 0012-186X [Print] Germany
• PMID: 11317665 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Insulin
• Insulin-Like Growth Factor Binding Protein 1
• Triglycerides
• Insulin-Like Growth Factor I
• Insulin-Like Growth Factor II
• Cholesterol

Topics

• Blood Glucose (metabolism)
• Blood Pressure (physiology)
• Body Constitution
• Cardiovascular Diseases (epidemiology)
• Cholesterol (blood)
• Diastole
• England
• Ethnicity
• Europe (ethnology)
• Fasting
• Female
• Glucose Tolerance Test
• Humans
• Insulin (blood)
• Insulin-Like Growth Factor Binding Protein 1 (blood)
• Insulin-Like Growth Factor I (metabolism)
• Insulin-Like Growth Factor II (metabolism)
• Male
• Middle Aged
• Pakistan (ethnology)
• Risk Factors
• Systole
• Triglycerides (blood)
• White People