Abstract |
The authors quantitatively measured levels of matrix metalloproteinases ( MMP), tissue inhibitor of metalloproteinases (TIMP), and vascular endothelial growth factor ( VEGF) in blood samples of POEMS syndrome. Circulating levels of MMP-1, -2, -3, -9, and TIMP-1 were more increased in patients with POEMS syndrome than in patients with other neurologic disorders or in healthy controls. Serum levels of VEGF and TIMP-1 were strongly correlated with each other. Increased circulating levels of MMP-1, -2, -3, -9, and TIMP-1 may lead to a better understanding the pathogenesis of POEMS syndrome.
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Authors | K Michizono, F Umehara, T Hashiguchi, K Arimura, E Matsuura, O Watanabe, N Fujimoto, Y Okada, M Osame |
Journal | Neurology
(Neurology)
Vol. 56
Issue 6
Pg. 807-10
(Mar 27 2001)
ISSN: 0028-3878 [Print] United States |
PMID | 11274326
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Endothelial Growth Factors
- Lymphokines
- Tissue Inhibitor of Metalloproteinase-1
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
- Matrix Metalloproteinase 3
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 9
- Matrix Metalloproteinase 1
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Topics |
- Endothelial Growth Factors
(blood)
- Immunoenzyme Techniques
- Lymphokines
(blood)
- Matrix Metalloproteinase 1
(blood)
- Matrix Metalloproteinase 2
(blood)
- Matrix Metalloproteinase 3
(blood)
- Matrix Metalloproteinase 9
(blood)
- POEMS Syndrome
(blood)
- Tissue Inhibitor of Metalloproteinase-1
(blood)
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
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