Intramembrane proteolysis by presenilins.

Abstract

Many neurodegenerative diseases involve the deposition of insoluble amyloid molecules. In Alzheimer's disease, for example, the amyloid beta-peptide (A beta) is the main component of the characteristic senile plaques. Proteolytic enzymes called secretases are involved in generating A beta, and one of these may have been identified as presenilin--a discovery that paves the way for a more complete understanding of presenilin structure and function.

• Authors: H Steiner, C Haass
• Journal: Nature reviews. Molecular cell biology (Nat Rev Mol Cell Biol) Vol. 1 Issue 3 Pg. 217-24 (Dec 2000) ISSN: 1471-0072 [Print] England
• PMID: 11252897 (Publication Type: Journal Article, Review)

Chemical References

• Amyloid beta-Protein Precursor
• Membrane Proteins
• PSEN1 protein, human
• PSEN2 protein, human
• Presenilin-1
• Presenilin-2
• Amyloid Precursor Protein Secretases
• Endopeptidases
• Aspartic Acid Endopeptidases
• BACE1 protein, human

Topics

• Alzheimer Disease (metabolism)
• Amyloid Precursor Protein Secretases
• Amyloid beta-Protein Precursor (genetics, physiology)
• Animals
• Aspartic Acid Endopeptidases
• Endopeptidases (physiology)
• Humans
• Membrane Proteins (chemistry, metabolism, physiology)
• Models, Biological
• Mutation
• Neurodegenerative Diseases (metabolism)
• Presenilin-1
• Presenilin-2
• Signal Transduction