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Presenilins

Integral membrane proteins and essential components of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. Mutations of presenilins lead to presenile ALZHEIMER DISEASE with onset before age 65 years.
Also Known As:
Presenilin
Networked: 874 relevant articles (3 outcomes, 48 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Shen, Jie: 20 articles (01/2021 - 04/2004)
2. De Strooper, Bart: 20 articles (01/2018 - 09/2002)
3. Wolfe, Michael S: 17 articles (01/2020 - 12/2002)
4. Steiner, Harald: 12 articles (01/2022 - 06/2002)
5. Haass, Christian: 12 articles (01/2016 - 06/2002)
6. Sisodia, Sangram S: 10 articles (01/2020 - 01/2002)
7. Fukumori, Akio: 9 articles (01/2022 - 01/2008)
8. Bezprozvanny, Ilya: 9 articles (10/2017 - 09/2006)
9. Berezovska, Oksana: 9 articles (01/2017 - 01/2003)
10. Checler, Frédéric: 9 articles (01/2017 - 03/2002)

Related Diseases

1. Alzheimer Disease (Alzheimer's Disease)
2. Dementia (Dementias)
3. Neoplasms (Cancer)
4. Neuroblastoma
5. Memory Disorders (Memory Loss)

Related Drugs and Biologics

1. Amyloid Precursor Protein Secretases (beta-Secretase)
2. Proteins (Proteins, Gene)
3. Amyloid (Amyloid Fibrils)
4. Peptides (Polypeptides)
5. Flavin-Adenine Dinucleotide (FAD)
6. Presenilin-1
7. Amyloid beta-Peptides
8. Amyloid beta-Protein Precursor (Amyloid Protein Precursor)
9. Enzymes
10. Calcium

Related Therapies and Procedures

1. Therapeutics
2. Transplantation
3. Heart Transplantation (Grafting, Heart)